摘要
儿童和青春期垂体腺瘤多数指16或18岁以前经手术证实的病例。全面评估内分泌、影像学改变是诊断的关键、治疗的基础。儿童和青春期PRL腺瘤与成人PRL腺瘤在对溴隐停有效性方面相同。甲介型或气化不良的蝶窦并不是经蝶手术的禁忌症。关于Cushing's病的治疗,首选经蝶手术,治愈率可达80％～98％。放射治疗应严格掌握适应症,尽可能减少延迟性的垂体功能低下的发生。术后可以发生各种垂体和下丘脑功能障碍,长期、正规的随访具有特别重要的意义。
The cutoff age for a pediatric and hebetic pituitary adenoma is 16 or 18 years old verified by surgery. The endocrinologic and iconographic investigation is the fundament and essence of diagnosis and treatment. Pediatric and hebetic prolactin adenomas respond to bromocriptine therapy as adult tumors do. A conchal or nonpneumatized type of sphenoid is not a contraindication to transsphenoidal surgery. The transsphenoidal microsurgery is optimal treatment in children and adolescents with Cushing's disease. The cure rate of pituitary ACTH adenomas is 80 %-98 %. Pituitary irradiation has been abandoned as the primary treatment due to the delayed onset of hypopituitarism. Pituitary or hypothalamic dysfunction after surgery may produce substantial morbidity in the pediatric patients with a pituitary tumor. Regular and long-term follow-up is of great importance.
出处
《中华神经医学杂志》
CAS
CSCD
2003年第3期236-238,共3页
Chinese Journal of Neuromedicine
