摘要
目的:初步探讨伽玛刀治疗高泌乳素血症性垂体腺瘤不孕症女性患者的疗效。方法:33例患有不孕症的高泌乳素血症性垂体腺瘤女性患者经过伽玛刀治疗,肿瘤体积平均值(1.09±1.05)cm3。给予治疗剂量:平均中心剂量(43.9±8.7)Gy,平均周边剂量(20.9±2.6)Gy。结果:31例患者经过16～71个月的随访,7例患者未能怀孕(2例由于子宫发育异常、3例人工避孕),1例因出现宫外孕人工流产,23例患者正常怀孕,所生育的15个婴儿发育正常。从MR影像上,肿瘤控制率为95.2%。虽然血清泌乳素水平因怀孕和哺乳而有波动,但有85.7%的患者高泌乳素血症减轻或消失。结论:立体定向放射外科伽玛刀并非是泌乳素分泌性垂体腺瘤患者的禁忌证,其能改善患者生育能力。
OBJECTIVE： To evaluate the effect of gamma knife treatment on female patients with infertility due to pituitary adenoma with hyperprolactinemia. METHODS： Thirty-three female patients with infertility due to pituitary adenoma with hyperprolactinemia received gamma knife treatment. The mean tumor size was （1.09± 1.05） cm^3. The prescription mean maximum dose was （43.9±8. 7） Gy and the mean margin dose was （20. 9±2.6） Gy. RESULTS： Among 31 patients who were followed up for 16- 71 months, 7 patients were not pregnant （2 patients due to uterine dysplasia, 3 patients because of contraception）. Ectopic pregnancy took place on 1 patients who finally had induced abortion. Thirty-three patients had uneventful pregnancies. All of the 15 delivered babies were of normal development. The tumor control rate was 95. 2% on MR. Although there was fluctuant on blood prolactine （PRL） level during the period of pregnancy or lactation, the hyperprolactinemia was less or disappeared in 85. 7 percent of the patients. CONCLUSION： Gamma knife surgery is not contraindication for patients with prolactine-secreting pituitary adenoma and it will improve their fecundity.
出处
《中华肿瘤防治杂志》
CAS
2007年第1期41-43,共3页
Chinese Journal of Cancer Prevention and Treatment
