摘要
本实验选用 8只健康家兔进行口服富铁酵母和硫酸亚铁的药物代谢动力学研究。试验采用双吡啶比色法测定血清铁浓度 ,药时数据经Mcpkp程序处理。家兔口服富铁酵母和硫酸亚铁的药时数据分别适合一室和二室开放模型 ,主要药代动力学参数 (平均值 ) ,富铁酵母为Tmax=2 73h ,Cmax=1 60 μg/ml,Ka=0 67h- 1 ,T1 / 2Ka=1 0 8h ,T1 / 2α=1 82h ,Kel=0 2 8h- 1 ,T1 / 2 β=9 73h ;硫酸亚铁为Tmax=2 62h ,Cmax=1 41μg/ml,T1 / 2Ka=0 94h ,Kel=0 2 4h- 1 ,T1 / 2K =3 0 5h。口服高铁酵母的生物利用度F(AUC富铁酵母 /AUC硫酸亚铁 ) % =12 2 % ,高于硫酸亚铁 ,为其 1 2 2倍 ,显示家兔口服富铁酵母要比硫酸亚铁好。
Objective: the eight health domestic rabbits were crossly administered high iron yeast and FeSO_4 orally to study its pharmacokinetics and bioavailability. Methods: In this experiment the serum concentration of iron was determined by spectrophotometer, and the data of drug-time were processed by MCPKP program. Result: The data of drug-time accorded with two and one ope n model , the main pharmacokinetic parameters of high iron yeast were: Ka=0.67 /h, Kel=0.28/h, Ka=1.08 h, T_(1/2 α)=1.82 h, T_(1/2 β) =9.73 h, T_ (max)=2.73 h, C_(max)=1.60 μg/ml, AUC=12.59 mg/ h^(-1) · l^(-1), FeSO_4 were T_(max)=2.62 h, C_(max)=1.41 μg/ml, T_(1/2Ka) =0.94 h, Kel=0.24 h^(-1),T_(1/2K) =3.05 h, Conclusions: bioavailability F (AUC ()_(high iron yeast)/ AUC()_(ferrisulphas)) % was 122%. The consequence indicated that the bioavailability of high iron yeast was 1.22 times that of ferrisulp has, and domestic rabbits absorbed the high iron yeast is better than ferrisulphas.
出处
《中兽医医药杂志》
2004年第2期9-12,共4页
Journal of Traditional Chinese Veterinary Medicine
基金
甘肃省自然基金资助项目
项目编号ZS0 0 1 -A2 1 - 0 36-N
