摘要
本文对膜片钳记录系统的背景噪声作了较全面的分析。系统噪声包括电子仪器噪声、封接噪声和电极噪声。仪器噪声有高频噪声等四种分量。作者提出了细胞膜与电极的封接阻抗的T型网络等效模型,分析指出,高阻(GΩ量级)封接的1/f噪声不可忽视。电极噪声有电极电阻噪声等三种分量,涂敷硅酮树脂(Sylgard)可以有效地降低电极噪声。
<ABSTRACT>
The background noises of patch clamp recording system are discussed
in detail. The system noise consists of electronic noise, seal noise and pi-
pette noise. The electronic noise has four noiseparts. The seal noise comse
from seal impedance. A seal-impedance model, Tnetwork model, is provi-
ded. In case of gigaseals, the 1/f noise from seal impedance could be an
important noise source. There are three components of the pipette noise,
which can be availably decreased by coating pipette with sylgard.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
1992年第2期128-137,共10页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金资助项目
关键词
膜片钳
噪声分析
电极
电容
: Patch clamp
Naiseanalysis
Pipette capacitance
