摘要
目的 :探讨大肠癌患者组织蛋白酶D表达与临床病理因素和预后的关系,为临床治疗的选择及预后判断提供依据。方法:对70例大肠癌患者手术标本组织蛋白酶D进行免疫组化检测,采用SPSS10.0版统计软件包对临床病理因素与预后进行相关的统计分析。结果:组织蛋白酶D表达在不同Dukes分期大肠癌中差异有显著性(P<0.05)。组织蛋白酶D表达与大肠癌组织浸润程度差异有显著性(P<0.01)。70例大肠癌患者术后5年总生存率为57.14%,而组织蛋白酶D表达对患者预后有影响 (P<0.05)。结论:组织蛋白酶D表达与大肠癌Dukes分期和肿瘤浸润程度均有相关性。大肠癌DukesC期肿瘤组织蛋白酶D的表达明显高于DukesA及B期,且肿瘤浸润深度愈深,组织蛋白酶D的表达愈高。组织蛋白酶D表达阳性的患者其5年生存率显著低于表达阴性的患者。组织蛋白酶D可作为预测大肠癌侵袭转移的独立性指标。
Objective:Exploring the expression of cathepsin D in patients of colorectal cancer and the correlations with clinicopathological parameters and prognosis to offer the foundation of the options of clinical treatments and the prognostic determinations.Methods:Using the method of immunohistochemistry to analyze cathepsin D of70samples in patients of post-coloprocˉtectomy.The correlatively statistical analyses between clinicopathological parameters and progˉnosis were made by the statistical software pack of SPSS10.0version.Results:The expression of positive cathepsin D had the significant differences in Dukes stages(P<0.05)and in the depth of tissue invasion of colorectal cancer(P<0.01).The5-year total survival rate was57.14%for70patients of post-coloproctectomy.The expression of cathepsin D could affect the patients'prognosis(P<0.05).Conclusion:There were the correlations with the expression of cathepsin D and Dukes stage of colorectal cancer or the degree of tumor invasion.The exˉpression of cathepsin D in tissue of colorectal cancer was significantly higher in Dukes C stage than in Dukes A or B stage.Furthermore,the deeper the tumor invaded into tissue,the higher the cathepsin D expressed.The5years survival rate was significantly lower in patients with positive cathepsin D than in those with negative one.Cathepsin D could be as the independent indicator to predict invasion and metastasis in colorectal cancer.It also could offer the founˉdation of prognostic determinations for patients with colorectal cancer.
出处
《天津医科大学学报》
2004年第1期50-52,共3页
Journal of Tianjin Medical University
关键词
大肠癌
组织蛋白酶D
转移
预后
Colorectal cancer
Cathepsin D
Metastasis
Prognosis
