摘要
本文观察了4种老年疾病患者的 HPAA 活动及相关肽 NPY 水平与外周血 T 细胞分裂原反应性的关系.结果表明,脑出血、脑梗塞患者 HPAA 活动增强,并与 NPY 水平增加呈伴随关系,HPAA、NPY与受抑的 T 细胞分裂原反应性呈负相关(P<0.01)。糖尿病患者 NPY、CRF、ACTH 含量与健康人比较无明显差异,皮质醇水平升高(P<0.05),后者与受抑的 T 细胞分裂原反应性无明显相关(P>0.05)。而原发性高血压疾病患者 HPAA 及 NPY、T 细胞分裂原反应性与健康者比较均无明显差异(P>0.05).上述资料提示,老年疾患 HPAA 活动及 NPY 水平因病种而异,其中脑血管意外患者的免疫功能变化与 HPAA 活动及 NPY水平有关.
The present study was designated to investigate relationship between HPAA activity,NPY levels and T—cell mitogenesis stimulated by PHA in aged patients.HPAA activity represented by CRF,ACTH and cortisol and NPY(a CRF—related neuropeptide)have been shown to be much higher in the cerebral hemorrhage(CH)and cerebral infarction(CI)patients compared with healthy aged,while T cell mitogenesis was inhibited markedly in CI and CH.Furthermore,
the decreased T cell mitogenesis and increased HPAA activity and,HPY levels were inversely related.In other aged patients such as diabetes mellitus(DM),the cortisol increased and T—cell mi-togenesis inhibited but no relationship between them was found.In the primary hypertension pa-tients,neither the activity of HPAA and NPY levels nor T—cell mitogenesis had changed obvi-ously.The data suggests that the immune function is modulated by the activities of HPAA and NPY—HPAA in cerebrovascular accident.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1992年第4期236-239,共4页
Chinese Journal of Immunology
关键词
HPAA
CRF
神经肽Y
Neuropeptide Y(NPY)
T—cell mitogenesis
Hypothalamo—pituitary—Adrenal Axia(HPAA)
