摘要
目的 探讨生物活性多肽处理的碳磷酸钙骨水泥 (carbonatedcalciumphosphatebonecement,CCPBC)修复牙周骨缺损的可能性与效果。方法 4只健康家犬牙周用手术方法去骨 ,缺损约1cm× 1cm ,每只犬分别用羟基磷灰石 (hydroxyapatite ,HA)、倍骼生、CCPBC以及用多肽处理的CCPBC直接修复缺损 ,术后 1～ 3个月进行X线片检查及组织形态学观察。结果 实验条件下 ,HA组和倍骼生组均有不同程度的材料丢失 ,HA组缺损处为软组织修复 ,倍骼生组牙槽骨侧残余材料周围有少量新生骨组织 ;CCPBC组能有效维持牙周骨缺损间隙 ;CCPBC经多肽处理组 ,材料周围有较多的新骨形成 ,修复效果优于其他组。结论 CCPBC经过生物活性多肽修饰后具有一定的成骨活性 ,其在牙周骨缺损修复中的应用前景 ,值得关注。
Objective To explore the possibility of repairing periodontal defects with carbonated calcium phosphate bone cement (CCPBC) modified with synthesized peptides . Methods Periodontal bone defects in 4 dogs were surgically created and then restored directly with hydroxyapatite ( HA), Perioglass , CCPBC and CCPBC modified with peptides.The results were compared at different levels. Results Bone replacement materials were lost in HA and Perioglass groups.In the HA group defects were restored with connective tissue .Perioglass group had only a little new bone around materials by alveolar bone.CCPBC could firmly stay in bone defects to maintain the space of bone defects even without membrane use.CCPBC modified with peptides was superior to HA ,Perioglass, and CCPBC , surrounded by a great deal of new bone. Conclusion Under limitation of this study , CCPBC modified with peptides has some osteoinuctive activity and may have good prospect for the clinical application in periodontal defect repair.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2003年第6期464-466,C003,共4页
Chinese Journal of Stomatology
