摘要
文章以高效液相色谱 (HPL C)法为定量手段 ,研究复方制剂中黄芩甙经子宫内灌注给药后在奶牛血浆和乳汁中药物代谢动力学特征。采用 MCPKP药代动力学程序处理药时数据 ,分析黄芩甙在血浆和乳中的药动学参数。结果表明 ,黄芩甙在血浆、乳中的药动学特征均符合一级吸收一室开放模型。黄芩甙在血浆中的主要药动学参数为 :C0=0 .37︼g· m L- 1 、Ka=1.73· h- 1 、K =0 .2 5· h- 1 、t1/ 2 Ka=0 .70 h、t1/ 2β=2 .93h、Cm ax=0 .2 4︼g· m L- 1 、Tmax=2 .2 3h、AU C=1.5 2 m g· (L h) - 1 、Tlag=0 .5 0 h。黄芩甙在乳汁中的主要药动学参数为 :C0 =0 .76︼g· m L- 1 、Ka=0 .88· h- 1 ,K=0 .38h- 1、t1/ 2 Ka=0 .79h、t1/ 2 β=1.82 h、Cm ax=0 .31︼g· m L- 1、Tmax=3.2 7h、AU C=2 .0 0mg· (L h) - 1、Tlag=1.6 0 h。
The samples of plasma and milk were acquired after five cows catching Endometritis were poured into their womb with the compound of Chinese herb.The drug concentrations in plasma and milk were determined by HPLC.The data were analyzed by MCPKP software.The data of baicalin in plasma were described by the one compartment open model.The main pharmacokinetics parameters of baicalin in plasma are C 0=0.37 μg·mL -1,Ka=1 73 h -1,K=0 25 h -1,t1/2Ka=0.70 h,t1/2β=2。93 h,Cmax=0.24 μg·mL -1,Tmax=2.23 h,AUC=1.52 mg·(Lh) -1,Tlag=0 50 h.The main pharmacokinetics parameter of baicalin in milk are C 0=0.76 μg·mL -1,Ka=0.88 h -1,K=0.38 h -1,t1/2Ka=0.79 h,t1/2β=1 82 h,Cmax=0.31 μg·mL -1,Tmax=3.27 h,AUC=2.00 mg·(Lh) -1,Tlag=1.60 h.
出处
《东北农业大学学报》
CAS
CSCD
2004年第2期167-171,共5页
Journal of Northeast Agricultural University
基金
黑龙江省科技厅攻关项目 ( G98B5 -4 )
