摘要
目的:探讨复方丹参滴丸对喂饲高脂饲料后家兔血脂水平和颈动脉硬化斑块的影响。 方法:48只家兔随机分为5组:正常对照组、动脉粥样硬化模型组、辛伐他汀组、复方丹参滴丸大、小剂量组。正常对照组喂饲基础饲料,其余4组均于每日喂饲40g高脂饲料,不足部分给予基础饲料,治疗组同时给药,辛伐他汀剂量为4mg/kg,小剂量复方丹参为0.013g/(kg·d),大剂量为0.117g/(kg·d);分别于实验前、实验12周末,经耳缘静脉抽 血,测定血脂含量。取血后空气栓塞处死家兔,迅速剥离颈动脉,进行病理学检查。 结果:复方丹参滴丸能显著降低实验家兔血清总胆固醇、三酰甘油、低密度脂蛋白(low density lipoprotein,LDL),升高血清高密度脂蛋白(high density lipoprotein,HDL)。并能减低血管内膜厚度(intima thickness,IT)及内中膜的厚度(intima-medium thickness,IMT)及其比率。与模型组相比辛伐他汀组及复方丹参小、大剂量组对内中膜厚度的抑制率分别为32％,24％,41％。 结论:复方丹参滴丸能减低实验性家兔血脂水平,抑制颈动脉粥样硬化的形成。
AIM: To explore the effects of fufang danshen diwan on the level of plasma lipid and arteriosclerosis in carotid artery in rabbits fed by high fat forage. METHODS: Forty-eight male New Zealand white rabbits were randomly divided into five groups: normal control group, atherosclerosis model group, simvastatin group, fufang danshen diwan large and small dose groups. Rabbits in the normal control group were fed by common forage, and other four groups were fed with 40 g high fat forage everyday, common forage was given if necessary. The treatment groups were treated by drugs at the same time: simvastatin 4 mg/kg, fufang danshen diwan small dose 0. 013 g/(kg · d) and large dose0. 117g/(kg · d). Plasma lipid were measured with the blood from the ear vein at the beginning and the end of 12th week. The rabbits were killed by air embolism after the blood was fetched, and carotid artery was stripped instantly for pathological examination.
RESULTS: Fufang danshen diwan could significantly reduce the total cholesterol, triglyceride and low density lipoprotein(LDL), and increase the high density lipoprotein(HDL) . Intima thickness (IT) and inlima-medium thickness (IMT) and their ratio were also reduced. Compared with the model group, the inhibitory rate of IMT in the simvastatin and fufang danshen diwan small and large groups were 32% , 24% and 41%.
CONCLUSION: Fufang danshen diwan can reduce the blood lipid level and inhibit the formation of atherosclerosis.
出处
《中国临床康复》
CSCD
2004年第9期1708-1709,F003,共3页
Chinese Journal of Clinical Rehabilitation
