摘要
目的 :评价动脉粥样硬化 (AS)性肾动脉狭窄患者的肾功能及与肾动脉狭窄之间的关系。方法 :10 9例非糖尿病患者经肾动脉造影发现存在AS肾动脉狭窄。根据其狭窄程度将患者分组。测定其肌酐清除率 ,采用单因素方差分析和相关分析判断肾动脉狭窄与肾功能之间的关系。结果 :单侧或双侧肾动脉狭窄 <6 0 %的患者 5 9例 ,肌酐清除率为 (6 7.3± 2 0 .9)ml/min ;单侧肾动脉狭窄≥ 6 0 %的患者 38例 ,肌酐清除率为 (6 5 .4± 18.3)ml/min ;双侧肾动脉狭窄≥ 6 0 %的患者有 12例 ,肌酐清除率为 (6 6 .3± 2 0 .3)ml/min ,各组间肌酐清除率差异无统计学意义 (P >0 .0 5 )。肾动脉的通畅程度与肾功能之间也无相关性 (r =0 .0 2 )。结论 :肾动脉狭窄的严重程度与肾功能之间差异无统计学意义。肾动脉狭窄所致的肾功能不全更有可能是肾实质病变造成的。
Objective:To investigate whether any relationship exists between renal function and the severity of proximal renal arterial lesions in patients with atherosclerotic renovascular disease.Method:A cohort of 109 patients had creatinine clearance measured at the time of digital subtraction angiography. The severity of proximal re-novascular lesions was estimated by standard methodology, and patients were subgrouped according to residual pa-tency of the proximal renal arteries.Result:One hundred and nine non-diabetic patients (mean ± s age 67.44± 8.27 years; 71 males) were suitable for study. No differences in renal function (mean±s creatinine clearance (ml/min)were seen among patients with unilateral RAS < 60% ( 67.3± 20.9, n= 59), unilateral RAS ≥ 60% ( 65.4± 18.3, n= 38), or bilateral ( 66.3± 20.3, n= 12) disease. No correlation existed between residual patency and creatinine clearance (r= 0.02); mean±SD renal function was almost identical in the four patency subgroups.Conclusion:These findings suggest that the severity of proximal renal artery lesions is often unrelated to the severity of renal dysfunction in patients with ARVD. Associated renal parenchymal damage is the more probable cause of renal dysfunction, and this should be considered when revascularization procedures are executed.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2004年第3期150-152,共3页
Journal of Clinical Cardiology
关键词
动脉粥样硬化
肾动脉狭窄
肾功能
Atherosclerosis
Renal artery stenosis
Renal function
