摘要
免疫组化法研究吡格列酮对糖尿病大鼠肾脏基质金属蛋白酶 2、9(MMP 2、9)和Ⅳ型胶原 (C Ⅳ )表达的影响。结果提示 ,吡格列酮治疗可逆转糖尿病大鼠MMP 2的下降 ,降低C Ⅳ的表达 ,从而可能延缓肾纤维化的进展。
Expression of matrix metalloproteinase (MMP)-2, MMP-9 and type Ⅳ collagen (C-Ⅳ) were studied by immunohistochemistry. After pioglitazone treatment, MMP-2 expression was increased and C-Ⅳ expression was decreased in diabetic rats, suggesting that the beneficial effects of pioglitazone on kidney could in part be mediated by modulation of changes in matrix degradative pathways.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2004年第5期459-460,共2页
Chinese Journal of Endocrinology and Metabolism
基金
浙江省自然科学基金资助项目 (30 0 50 6)
浙江省卫生厅基金资助项目 (2 0 0 3A0 35)
关键词
糖尿病大鼠
吡格列酮
基质金属蛋白酶2
表达
肾组织
MMP-2
治疗
Diabetic nephropathies
Pioglitazone
Matrix metalloproteinase-2
Matrix metalloproteinase-9
Collagen type Ⅳ
