缬沙坦联合双嘧达莫治疗老年高血压合并肾功能不全的临床分析被引量：2

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摘要目的：观察缬沙坦联合双嘧达莫治疗老年高血压合并肾功能不全的临床效果.方法：选取2011年1月-2012年12月在本院门诊诊治的老年高血压合并肾功能不全的患者58例,并随机分为对照组30例,观察组28例.对照组单纯予缬沙坦80～160 mg/d;观察组予缬沙坦80～160 mg/d,联用双嘧达莫片50 mg,tid,两组疗程均为8周.结果：两组治疗后血压及肾功能均明显改善（P〈0.05）,观察组血压及肾功能方面较对照组改善更明显（P〈0.01）.结论：采用缬沙坦联合双嘧达莫治疗老年高血压合并肾功能不全的临床疗效优于单纯使用缬沙坦.

作者单艳肖海刚

机构地区江苏省建湖县第三人民医院心内科

出处《南通大学学报（医学版）》 2013年第5期422-423,共2页 Journal of Nantong University(Medical sciences)

关键词高血压病肾功能不全缬沙坦双嘧达莫

分类号 R544.4 [医药卫生—心血管疾病]

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11999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hyperten- sion. Guidelines Subcommittee[J]. J Hypertens, 1999, 17(2): 151-183.
2陆再英,钟南山.内科学[M].7版.北京:人民卫生出版社,2007:712-717.
3倪钧,沈卫峰,张瑞岩,胡健,张宪.影响冠心病并肾动脉狭窄患者肾动脉支架术后血压改善因素的探讨[J].临床心血管病杂志,2005,21(8):452-454. 被引量：3
4王远英,孙承美.高血压肾损害的诊断与治疗[J].社区医学杂志,2008,6(14):3-4. 被引量：6
5胡大一,赵秀丽.血管紧张素Ⅱ受体拮抗剂治疗高血压的研究进展[J].现代康复,1999,3(10):1204-1206. 被引量：6
6Schmermund A, Lerman LO, Ritman EL, et al. Cardiac production of angiotensin II and its pharmacologic inhibi- tion: effects on the coronary circulation[J]. Mayo Clin Proc, 1999, 74(5):503-513.

二级参考文献17

1马剑英,郝义滨,李家荣,李敬田,姚荣国,宋书剀,郭战利.冠心病患者肾动脉狭窄发病率分析[J].临床心血管病杂志,2004,20(7):434-434. 被引量：3
2张素英,李瑜,李改香.依那普利联合科素亚对原发性高血压早期肾损害的影响[J].中西医结合心脑血管病杂志,2006,4(10):869-870. 被引量：8
3Buller C E,Nogareda J G,Ramanathan K,et al.The profile of cardiac patients with renal artery stenosis.J Am Coll Cardiol,2004,43:1606-1613.
4Leetouwer T C,Gussenhoven E J,van Jaarsveld BC,et al.Stent placement for renal arterial stenosis:where do we stand? A meta-analysis.Radiology,2000,216:78-85.
5Watson P S,Hadjipetrou P,Cox S V,et al.Effect of renal artery stenting on renal function and size in patients with atherosclerotic renovascular disease.Circulation,2000,102:1671-1677.
6Zeller T,Frank U,Muller F,et al.Predictor of improved renal function after percutaneous stent-supported angioplasty of severe atherosclerotic ostial renal artery stenosis.Circulation,2003,108:2244-2249.
7Bhatt D B.Embolization-a pathological mechanism in renal artery stenosis.J Invasive Cardiol,2004,16:196-197.
8Zeller T,Frank U,Muller C,et al.Stent-supported angioplasty of severe atherosclerotic renal artery stenosis preserves renal function and improves blood pressure control:Long-term results from a prospective registry of 456 lesions.J Endovasc Ther,2004,11:95-106.
9Rundback J H,Sacks D,Kent K C,et al.Guidelines for the reporting of renal artery revascularization in clinical trials.Circulation,2002,106:1572-1585.
10陈修等.心血管药理学[M]人民卫生出版社,1997.