摘要
目的 :探讨原发性高血压 (EH)代谢综合征与血管紧张素转换酶 (ACE)基因插入 /缺失多态性的关系。方法 :选取EH患者 2 0 2例 ,其中男 116例 ,女 86例 ,年龄 30～ 72 (5 9.5 4± 9.2 6 )岁。符合代谢综合征者 10 6例 ,非代谢综合征 96例。应用聚合酶链反应 (PCR)测定两组ACE基因插入 /缺失多态性。结果 :EH代谢综合征组与非代谢综合征组ACE基因DD、ID、II基因型间无显著相关性 (χ2 =2 .5 4 5 ,P 0 .0 5 )。代谢综合征组ACE多态性基因型与腰围、高密度脂蛋白胆固醇 (HDL C)密切相关 (P <0 .0 1) ;与腰围 /臀围、三酰甘油 (TG)密切相关 (P <0 .0 5 ) ;与血压、血糖、胰岛素无关 (P 0 .0 5 )。代谢综合征组ACE基因DD、ID基因型腰围较II基因型显著增加 (P <0 .0 1,<0 .0 5 ) ;DD基因型腰围 /臀围、TG较II基因型显著增加 (P <0 .0 5 ) ;ACE基因DD基因型HDL C较II基因型显著降低 (P <0 .0 5 ) ;ACE基因DD、ID、II基因型间血压、血糖、胰岛素差异无统计学意义 (P 0 .0 5 )。结论 :EH代谢综合征与ACE基因多态性无显著相关性。但是代谢综合征患者肥胖、脂代谢紊乱与ACE基因多态性密切相关 ,而血压水平、胰岛素敏感性却与ACE基因多态性无关。
Objective:The purpose of this study was to detect the relationship between metabolic syndrome (MS) and angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in essential hypertensive (EH) patients.Method:Two hundred and two EH patients were observed. Multiple polymerase chain reaction (PCR) was used to evaluate the ACE gene I/D polymorphism. Insulin resistance was evaluated by insulin sensitivity index (ISI).Result:There was not difference of ACE genotype polymorphism between metabolic syndrome group and non MS group in EH patients (χ 2= 2.545, P 0.05). ACE polymorphic genotype is related to waistline and HDL-C(P 0.01), to ratio of waistline and hipline and Triglycerides(P 0.05),but not to blood pressure, serum glucose or insulin(P 0.05). The waistline of ACE gene DD genotype and ID genotype is higher than that of II genotype in MS group of EH patients (P 0.01, P 0.05). The ratio of waistline and hipline and Triglycerides of ACE gene DD genotype are higher than those of II genotype in MS group of EH patients (P 0.05), and HDL-C of DD genotype is lower than that of II genotype of MS group of EH patients(P 0.05), but there was no difference in blood pressure, serum glucose and insulin between different gene types(P 0.05).Conclusion:ACE gene insertion/deletion (I/D) polymorphism is not related to the MS of EH patients. But ACE gene polymorphism is related to the obesity and disorder of lipid metabolism of MS, and not to blood pressure level and insulin sensitivity of MS in EH patients.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2004年第3期139-141,共3页
Journal of Clinical Cardiology
关键词
高血压
代谢综合征
血管紧张素转换酶
基因
Hypertension
Metabolic syndrome
Angiotensin converting enzyme
Gene
