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血管紧张素转换酶基因多态性与新疆地区高血压病相关性研究 被引量：1

A study on association of insertion/deletion polymorphism of the angiotensin coverting enzyme gene with essential hypertension in Xinjiang
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摘要 目的 :了解血管紧张素转换酶 (ACE)基因多态性与新疆地区原发性高血压的易感相关性。方法:应用聚合酶链反应 (PCR)对 78例新疆地区原发性高血压患者与 72例正常血压对照者 ACE基因第 16内含子插入 /缺失多态性进行鉴定。结果:在新疆地区原发性高血压患者中 ,ACE基因缺失纯合基因型 (DD)和缺失 (D)等位基因频率均明显高于正常血压者 (P <0 .0 5及 P <0 .0 1)。 Objective: To asses whether the insertion/deletion(I/D) polymorphism of angiotensin coverting enzyme (ACE) gene was associated with essential hypertension in xinjiang. Methods: I/D polymorphism of ACE was determined by polymerase chain reaction (PCR) in 72 normal controls, 78 patients with essential hypertension. Results: The frequencies of DD gene type (0.30) and deletion allele (0.53) among essential hypertension were significantly higher than those (0.14) among control subjects (0.375). Conclusion: The results indicate that a deletion polymorphism of ACE gene probably may be the risk factor in essential hypertension in xinjiang.
作者 张源明 关亚群 木尼热.吾布力
机构地区 新疆医科大学临床医学院 新疆医科大学基础医学院
出处 《新疆医科大学学报》 CAS 2003年第2期143-145,共3页 Journal of Xinjiang Medical University
基金 新疆医科大学第一附属医院硕士启动基因项目 (98-XYQD-0 5 )
关键词 血管紧张素转换酶 基因多态性 新疆地区 高血压 相关性研究 Angiotensin converting enzyme gene I/D polymorphism essential Hypertension
分类号 R544.1 [医药卫生—心血管疾病]
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  • 1Srivastava K, Sundriyal R, Meena PC, et al. Association of angiotensin converting enzyme (insertion/deletion) gene poly morphism with essential hypertension in northern indian sub jects[J]. Genet Test Mol Biomarkers, 2012,16(3):174-177.
  • 2Duru K, Farrow S, Wang JM, et al. Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in african-americans with hypertension [J]. Am J Hypertens, 1994,7(8):759 -762.
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新疆医科大学学报
2003年 第2期

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