摘要
支气管肺泡灌洗术(BAL)已应用于临床治疗尘肺,但进展不快,主要是对其可行性和可能性仍有异议。为促进BAL这一新方法在矽肺治疗中的应用,本实验通过对不同柒尘时间矽肺大鼠支气管肺泡灌洗液(BALF)中排出物含量动态变化观察,就其可能性进行探讨。实验结果表明:不同染尘时间实验组BALF中的细胞总数、LDH活性、总蛋白含量均高于对照组,且有非常显著差别(P<0.01),尤以来尘7、15、30天差异更为显著。提示:BAL可以洗出大量细胞及非细胞成份,对减轻肺泡炎、减少肺部损伤将有积极作用,且以早期或急性矽肺施行BAL为宜。
Bronchalveolar lavage (BAL) has been used to treat pneumoconiosis, but its development is limited due to some objections in its feasibility and possibility. In order to promote the application of BAL in silicotic therapy an animal model of silicosis in rats had been developed and its possibility had been studied by determining indices in bronchalveolar lavage fluid (BALF). We found that total cell numbers, the lactic dehydrogenase activities, and the concentrations of protein in experimental rats were significantly higher than that of control (P<0.01). Furthermore, the differences between experimental groups and control at 7,15,30 days after instillation were more significant. It suggested that BAL could play an active role in removing a lot of cells and other substances, alleviating alveolitis, and reducing lung damage. The results also revealed that BAL might be more effective in early stages of silicosis or acute silicosis.
出处
《职业医学》
1992年第3期141-143,共3页
China Occupational Medicine
关键词
石英
支气管肺泡
灌洗术
矽肺
quartz,experiment silicosis,bronchalveolar lavage,silicosis,therapy
