摘要
目的 :观察解毒护肝汤体内抗鸭乙型肝炎病毒 (DHBV)的作用。方法 :采用人工感染鸭乙型肝炎病毒的武汉麻鸭为动物模型 ,用解毒护肝汤口服治疗 2W ,观察用药前后血清DHBV -DNA含量及肝组织HE染色的病理改变 ,并以阿昔洛韦作阳性对照。结果 :解毒护肝汤治疗后鸭血清DHBV -DNA的含量明显低于给药前 ,有显著性差异 (P <0 0 5 ) ;治疗组、阿昔洛韦组的中位抑制率与模型组比较有显著性差异(P <0 0 5 ) ;治疗组的肝细胞点状坏死和碎屑样坏死与阿昔洛韦组相比有显著性差异 (P <0 0 5 )。结论 :解毒护肝汤连续用药后在鸭体内有抗乙型肝炎病毒作用。
Objective:To study the antiviral effect of jieduhugan decoction on duck hepatitis virus(DHBV) in vivo.Methods:The Wuhan duck hepatitis B model was treated with Chinese herb decoction for 2 weeks.DHBV-DNA in serum was detected by dot-blot hybridization test,the morphic changement of liver tissue after carrying on experiment was observed.the result was contrasted with acyclovir. Results:After giving medication with jieduhugan decoction for 14 days,the optic density value of DHBV-DNA in ducks' serum were obivously lower than that before treated,there were remarkable difference ( P <0 05),The medial inhibitory rate of DHBV-DNA between treatment group and model group was significant different ( P <0 05) Spotty and fragmentary necrosis of hepatocyte in treatment group was improved more obviously than that in western medicine group.Conclusion: Jieduhugan decoction has certain antiviral effect in duck body after continuously taken.
出处
《中国中医药科技》
CAS
2004年第2期77-78,共2页
Chinese Journal of Traditional Medical Science and Technology
