摘要
目的 探讨可乐定 (Clo)对福尔马林致痛大鼠的行为学影响机制。方法 制备福尔马林致痛模型 ,观察可乐定 (Clo)、NO前体 (L- Arg)和 NOS抑制剂 L- NG-硝基精氨酸甲酯 (L- NAME)对模型鼠缩腿舔爪时间的影响。结果 Clo组的缩腿舔爪时间 (38.6 0± 17.34) s/ 5 m in显著短于模型鼠组 (15 5 .4 1± 2 2 .0 4 ) s/ 5 m in,预先给予L- Arg或 L- NAME分别能加强或抑制以上作用。结论 可乐定能引起大鼠脊髓背角 NO的释放 。
Objective To assess the effect of Clonidine on SD rat's behavior response and spinal nitric oxide in the formalin test. Methods The effects of Clonidine (Clo), L-arginine(L-Arg), and NG-nitro-L-arginine (L-NAME) on the flinching and licking time of rats in the formalin test were assessed using the model of formalin-induced hyperalgia. Results The flinching and licking time of group Clo was shorter (38.60±17.34) s/5 min than that of group Formalin(155.41±22.04) s/5 min. Pre-administration of L-Arg could potentiate the Clonidine-induced response; pre-administration of L-NAME could reduce the Clonidine-induced response. Conclusion Spinal nitric oxide release might be one of the antinociception mechanisms of Clonidine in the formalin test.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2004年第2期232-233,250,共3页
Journal of Sichuan University(Medical Sciences)
