摘要
目的研究局部外周应用氯诺昔康对大鼠福尔马林致痛模型的镇痛作用.方法雄性SD大鼠随机分为对照组、同侧给药组、对侧给药组.给药30 min后于给药侧或给药对侧后爪足底皮下注射20 g/L福尔马林50 μl,观察其后60 min内每5 min大鼠咬舔注射福尔马林爪的时间变化. 结果大鼠注射福尔马林后第一相(0～10 min)咬/舔后爪累积时间,给药组与对照组比较差异无统计学意义(P>0.05).第二相(10～60 min)同侧给药组各剂量与对照组比较咬/舔后爪累积时间减少,差异有统计学意义(P<0.05).结论局部外周应用氯诺昔康对大鼠福尔马林致痛模型的第二相有镇痛效应,此效应主要为局部效应而非全身效应.
Objective To investigate analgesic actions after local peripheral administration of Lornoxicam in an animal model of formalin test. Methods Male Spague-Dawley rats were randomly divided into 3 groups, namely the control, the ipsilateral and the contralateral groups. Each group consisted of 8 rats. Thirty minutes prior to subcutaneous injections of 20 g/L formalin 50 μl into the plantar surface of the right hind-paw, the rats of ipsilateral group received Lornoxicam in the plantar surface of the right hind-paw, and the rats of contralateral group received Lornoxicam in the contralateral plantar surface of the hindpaw. Pain response was recorded for a period of 60 minutes. The summation of time （in seconds） spent in licking and biting responses to the injected paw during each 5 minutes block was analyzed for comparison. Results The pain response in the first phase （from 0 to 10 minutes） was not inhibited （P〉0.05）. The pain response in the second phase （from 10 to 60 minutes） was inhibited in the ipsilateral group （P〈0. 05）. Conclusion Local peripheral administration of Lornoxicam has analgesic effect on the rat＇s planta in the second phase of a formalin test model; the mechanism involved is mainly local, but not systemic.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2005年第5期703-705,共3页
Journal of Sichuan University(Medical Sciences)
