摘要
目的 :探讨肝纤维化血清标志物Ⅳ型胶原 (Ⅳ -C)、层粘蛋白 (LN)、透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )在肝病诊断中的意义。方法 :采用放射免疫分析 (RIA)对 36 1例肝病患者、5 2例健康体检者血清中Ⅳ -C、LN、HA、PCⅢ进行检测 ,同时与对照组比较。结果 :慢性迁延型肝炎 (CPH)、慢性活动型肝炎 (CAH)、肝炎后肝硬化 (LC)血清中Ⅳ -C、LN、HA、PCⅢ含量与对照组相比均有不同程度升高 (p <0 0 1或p<0 0 0 1 ) ,且随着病程的发展逐渐升高 ,肝硬化时升幅最大 ,其中以HA升高幅度最为明显。结论 :血清Ⅳ -C、LN、HA、PCⅢ测定可较好地反映肝纤维化程度 。
Objective To investigate the diagnostic significance of determination of the four serum hepatic fibrosis indicators levels in patients with liver diseases. Methods The serum contents of Ⅳ-C, LN, HA and PCⅢ in 361 patients with varous types of liver diseases (CPH 92, CAH 82, LC 187) and 52 controls were determined with RIA. Results Serum contents of these 4 indicators in patients of all the types were significantly higher than those in controls ( p<0 01 to p <0 001). With the progress of the disease process toward development of cirrhosis, the contents were correspondingly increased with HA most marked. Conclusion Determination of serum Ⅳ-C, LN, HA and PCⅢ levels could be useful for reflection of the degree of hepatic fibrosis. For diagnosis of cirrhosis, HA seems to be most valuable.
出处
《放射免疫学杂志》
CAS
2004年第1期23-25,共3页
Journal of Radioimmanology
