摘要
目的 :观察慢性乙型肝炎患者血清中Ⅳ型胶原 (CⅣ )、Ⅲ型前胶原 (PCⅢ )、透明质酸 (HA)和层粘蛋白 (LN)的变化及临床意义。方法 :采用放射免疫分析对 172例受检者 (其中乙肝患者 12 9例 ,正常对照者4 3例 )血清中CⅣ、PCⅢ、HA和LN进行检测。结果 :在慢性乙肝患者血清中CⅣ、PCⅢ、HA和LN水平均较正常对照组显著升高 (p <0 0 1)。随着病程的进展 ,CⅣ、PCⅢ、HA和LN四项指标在患者血清中均呈逐渐上升趋势 ,在肝硬化时达到最高。结论 :在慢性乙型肝炎患者中 ,血清CⅣ、PCⅢ、HA和LN等指标 ,可以较好地反映肝纤维化的程度。
Objective To explore the clinical significance of changes of serum type collagen Ⅳ(CⅣ), type precollagen Ⅲ(PCⅢ), hyaluronic acid(HA) and laminin(LN) levels in chronic hepatitis B patients. Methods Serum CⅣ, PCⅢ, HA and LN levels were measured with radioimmunoassay in 129 patients with chronic hepatitis B and 43 controls. Results Serum CⅣ, PCⅢ, HA and LN levels in chronic hepatitis B were siginificantly higher than those in the controls ( p <0 05). Serum concentration of CⅣ, PCⅢ, HA and LN gradually increased as the dicease progerssing and reached the highest levels in liver cirrhosis. Conclusion The results suggest that serum CⅣ, PCⅢ, HA and LN levels can reflect the degree of hepatic fibrosis in chronic hepatitis B patients.
出处
《放射免疫学杂志》
CAS
2003年第1期30-31,共2页
Journal of Radioimmanology
