摘要
目的 :探讨慢性乙肝病毒 (HBV)携带者血清甘胆酸 (CG)水平与肝功能早期损害的关系。方法 :对 384例慢性HBV携带者和 1 2 0例健康人对照 ,用RIA进行血清CG检测 ,同时随机抽取 40例病例做肝组织活检。结果 :慢性HBV携带者血清CG含量为 6 .62±4.2 4mg/L ,明显高于正常健康对照组的 1 .49± 0 .71mg/L(P <0 .0 1 ) ,但HBeAg阳性组与HBeAg阴性组血清CG含量无明显差异 (P >0 .0 5) ,其中HBeAg阳性组CG含量超过正常上限者 66例 (34 .38% ) ,HBeAg阴性组CG含量超过正常上限者 56例 (2 9.1 7% ) ,两者无明显差异 (P >0 .0 5)。病例组血清CG含量与CG异常率随年龄增长有明显增高趋势 (P <0 .0 1 )。 40例病理分析 ,34例 (85 .0 0 % )出现不同程度的炎症性和纤维化改变。且与CG含量呈明显正相关。结论 :慢性HBV携带者多存在早期肝脏损害 ,血清CG检测是一项无创、敏感的肝功能指标 ,它反映肝脏早期受损的程度 ,动态观察肝脏受损情况 。
Objective: To investigate the relationship between content of serum chotyglycine (CG) and early liver injury in chronic cases carrying hepatitis B virus (HBV). Methods: In clinical data of 384 cases with HBV and 120 normal control group, serum concentration of CG was measured by radioimmunoassay(RIA). The pathological characteristics were investgated in 40 cases randomly. Results: Serum concentrations of CG were 6.62±4.24 mg/L , 1.49±0.71 mg/L in chronic cases carrying HBV and normal persons respectively ( P <0.01).The difference of serum CG contents were not significant between HbeAg(+) and HbeAg( ) patienty( P >0.05). In the patient groups[HbeAg (+) and HibeAg( )], the content of serum CG rised with the age. The pathological characteristics showed hepatic inflammation and fibrosis with difference degree a positive rate of 85% (34/40). Conclusion: Early liver injury occurs in chronic cases carrying HBV, the measurement of serum CG is a harmless and sensitive index to early liver injury.
出处
《临床消化病杂志》
2004年第1期25-27,共3页
Chinese Journal of Clinical Gastroenterology
关键词
甘胆酸
乙肝病毒
肝脏损害
Cholyglycine
Hepatitis B virus
Liver harm
