摘要
为了解慢性乙型肝炎（乙肝）患者是否有前Ｃ区基因突变及其与临床的关系，应用快速检测乙型肝炎病毒（ＨＢＶ）前Ｃ区基因突变方法，对５３例患者进行了研究。结果显示：２５例ＨＢＶＤＮＡ阳性患者中１３例有突变株感染，最常见的突变形式为１８９８位或伴有１９０１位突变（１０／１３例）。突变株检出率与性别、年龄、乙肝家族史及血清丙氨酸转氨酶（ＡＬＴ）水平无关，病程＞５年的患者检出率有增高趋势。突变株检出主要集中在抗－ＨＢｅ阳性患者中（７７．８％），并随肝组织炎症程度加重而增加，重型肝炎患者突变株检出率最高（６６．７％）。研究结果提示，突变株的产生可能与机体免疫压力的选择有关。
To examine whether there are precore mutants in patients with type B chronic hep-atitis and its clinicai relevance,we used rapid detection method for hepatitis B virus(HBV)precoremutation in 53 patients.The results showed that of 25 HBV DNA positive patients,13 patientswere infected by mutants or coinfected by precore mutants and wild type strain,The mutation at nt1898 or/and nt 1901 was the most common mutation(10/13).It was found that there were no cor-relation between infection with precore mutants and sex,age,family history of HBV infection,andserum level of ALT,Patients with clinical course>5 years had an increasing detection rate of pre-core mutants.Precore mutants were mainly found in anti-HBe positive patients(77.8%).Therewas a higher detection rate of precore mutants in patients with severe hepatitis(66.7%),andseemed associated with the severity of liver inflammationThe results suggest that the occurrence ofprecore mutants may be associated with immune selective pressure in the infected host.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
1996年第1期15-19,共5页
Chinese Journal of Infectious Diseases
基金
欧洲共同体科技合作基金
中法合作项目资助
关键词
乙型肝炎
乙型肝炎病毒
前C区
突变
临床
Type B chronic hepatitis Hepatitis B virus Precore mutation Clinical relevance
