摘要
将聚砜为材料的中空纤维膜组件应用于丙烯腈水合转化为丙烯酰胺的微生物转化和膜分离耦合过程,对其特性进行了初步研究.结果表明:该膜对此反应体系有很好的适用性,通过中空纤维膜使反应液和菌体得到有效的分离,实现了膜分离耦合的酶催化反应过程.20℃时,在不更新菌液的情况下,持续操作5h,丙烯腈转化率达到99%,发酵菌液可催化合成丙烯酰胺2.722g/(mL·h),产物中没有检测到副产物丙烯酸.膜材料的应用研究为长期连续化生产过程的研究打下了基础.该工艺过程以自由细胞替代固定化细胞,实现了连续化操作,具有良好的工业应用前景.
The bioconversion of acrylamide coupling with polysulfone hollow-fiber membrane separation process were studied. The results showed that the polysulfone hollow-fiber membrane is very applicable to the bioconversion process. Applying the membrane to the bioconversion process, the free cell replaced the immobilized cell as catalyzer in the reaction system. At 20 ℃ and the bioconversion time over 5 h without renewing the bacterium, the conversion rate of acrylonitrile was 99%, and the productivity of acrylamide was 2.722 g/(mL·h). This process provide a promising technology for the continuous bioconversion of acrylamide in industry.
出处
《膜科学与技术》
CAS
CSCD
北大核心
2004年第1期11-15,共5页
Membrane Science and Technology
基金
国家自然科学基金资助项目(20206014)
