摘要
电穿孔是在脉冲电场作用下细胞膜暂时出现微孔的物理过程 ,其结果是细胞内外分子交换显著增加 ,有利于细胞吸收各种药物、基因物质、蛋白质和其它大分子等。电场取消后微孔关闭而不会对细胞造成任何影响。电穿孔对于研究脉冲电场作用下细胞的结构和功能有重大意义 ,这种瞬时可逆的膜渗透性增强大大促进了化疗药物的跨膜运送 ,有效地提高了其杀伤力 。
Electroporation is a physical process inducing transient bores in cell membranes by the application of pulsed electric fields. There is a significant increase in the exchange of molecules between the cell interior and exterior. The transient, reversible nature of this electrical permeabilization of membranes facilitates the cellular uptake of various drugs, genetic material, proteins, other micro and macromolecules. When the electric fields are cancelled, the bores will be closed. It is important that electroporation is employed as a research tool to study the cell structure and function under pulsed electric fields. The increasing permeability of cell membrane promotes higher uptake of chemotherapeutic drug and enhanced killing of the cancer cells. Electroporation provides a new method for tumor treatment undoubtedly.
出处
《高电压技术》
EI
CAS
CSCD
北大核心
2004年第1期45-47,51,共4页
High Voltage Engineering
基金
国家自然科学基金资助项目 (5 0 0 770 2 7)
关键词
肿瘤治疗
细胞膜电穿孔
膜渗透性
化疗药物
脉冲电场
electroporation cell membrane tumor treatment irreversible electrical breakdown
