摘要
近年来 ,电工技术已广泛用于生物医学工程研究中 ,而将脉冲电场用于肿瘤治疗的研究横跨生物医学工程、电工新技术、计算机技术和微电子技术等领域 ,是一门新兴的边缘学科。国内外的专家对在脉冲电场作用下细胞膜发生电穿孔的现象进行了深入的研究与临床试验 ,研究结果表明细胞膜电穿孔能促进化疗药物的运送 ,从而有效地提高了化疗药物的杀伤力。研究者们还大胆地探索了高电场强度的陡脉冲促使肿瘤细胞发生不可逆性电击穿 (IREB)
In these years, the electrical technology is widely applied in the study of biomedical engineering. Using electroporation therapy (EPT) to treat tumor is associated with biomedical engineering, electrical new technology, computer technology and microelectronic technology, which is a new marginal subject. Many experts have studied the mechanism and clinical treatment of the cell membrane electroporation phenomenon under electrical fields. These researches have shown that the membrane electroporation can stimulate the transport and intake of various drugs, which improves the tumoricidal effect of these drugs. The researchers have also been exploring the phenomenon that irreversible electrical breakdown (IREB) of cell membrane under high electrical fields and steep pulses leads to the death of tumor.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2002年第2期337-339,共3页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目 (5 0 0 770 2 7)
