摘要
目的 :对阿霉素聚乳酸微球的制备工艺、含量测定及体外释药特性进行初步研究。方法 :以人工合成可生物降解聚合物聚乳酸为载体 ,采用乳化 溶剂挥发法制备阿霉素聚乳酸微球 ,用UV - 2 60紫外分光光度计测定其药物含量和体外释药量。结果 :所制备的阿霉素聚乳酸微球外形圆整 ,算术平均球径为 55 .2 μm ,载药量为30 .2 1 μg·mg- 1 ,1 2h体外累积释药量36 %。结论 :聚乳酸微球具有很好的控释能力 ,使用前景广阔。
OBJECTIVE To study the preparation process, assay and in vitro drug release of adriamycin polylactic acid microspheres.METHODS Adriamycin polylactic acid microspheres were prepared by emulsifying solvent-evaporation process. Content and amounts of accumulitive release in vitro were determined by the ultraviolet spectrophotomethy(UV) method.RESULTS The microspheres were round and its surface was smooth. Arithimetic mean diameter was 55.2 μm , amount of carrier drug were 30.21μg ·mg -1 , the accumulative release percentage was 36% in 12 hours.CONCLUSIONS The controlled-release effect of adriamycin polylactic acid microspheres was good, it might be used widely.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2004年第2期74-75,共2页
Chinese Journal of Hospital Pharmacy
基金
山西省科委攻关项目 (编号 :96 2 113)
关键词
阿霉素聚乳酸微球
乳化溶剂挥发法
体外释放
adriamycin polylactic acid microspheres
emulsifying solvent-evaporation process
release behaviour in vitro
