摘要
目的 探讨中医证候与组织纤溶酶原激活物 (t PA)、组织纤溶酶原抑制物 (PAI)的关系。方法 按病例纳入标准进行临床观察并填写临床观察表格 ,将表格内容与所观察到的中医证候进行统计学分析。结果 气虚组t PA水平与其余各组均有显著性差异 (P <0 0 1) ,但与气虚血瘀组及气阴虚组无显著性差异 (P >0 0 5 ) ;气阴虚组PAI水平与其余各组均有显著性差异 (P <0 0 1) ;t PA与PAI显著相关 ,r=0 82 7。结论 t PA、PAI是内皮损伤的标志物之一 ,对血瘀证具有相对特异性。
Objective To investigate the relationship between the TCM syndromes in acute cerebral infarction and the two biochemical criteria, tissue plasminogenemia activator (t PA) and plasminogenemia activator inhibitor (PAI) in the plasma. Methods Clinical observation was carried out according to the TCM diagnostic criteria for selecting the cases, and observation forms were filled accordingly. The data were statistically analyzed. Results There was a significant difference between the level of tPA in the qi deficiency group and that in other groups ( P <0.01); however, there was no significant difference between the level of tPA in the qi deficiency group and that in both the qi deficiency and blood stagnation group and the qi yin deficiency group ( P >0.05); again, there was a significant difference between the level of PAI in the qi yin dificiency group and that in other groups ( P <0.01). The results of the observation showed that tPA and PAI were closely correlated, with r=0.827. Conclusion Both tPA and PAI are markers of endothelial injuries, and they are the relatively specific criteria for diagnosing TCM blood stagnation syndrome.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2004年第1期60-62,共3页
Journal of Beijing University of Traditional Chinese Medicine
关键词
脑梗塞
中医证候
临床研究
组织纤溶酶原激活物
组织纤溶酶原抑制物
Cerebral Infarction
TCM Syndrome
Clinical Research
Tissue Plasminogenemia Activator
Plasminogenemia Activator Inhibitor
