摘要
目的:比较果糖与葡萄糖静脉输注后对血糖水平的影响,评价其用于临床能量补充的有效性与安全性。方法:采用随机、双盲平行对照试验,41例住院患者分为试验组和对照组两组,分别每天接受50g/L果糖或50g/L葡萄糖注射液25g,连续3d,于给药前、给药结束时、给药后2h测定血糖浓度,并同时于试验前和试验结束后检测肝、肾功能。结果:20例住院患者静脉输注50g/L果糖注射液后即刻血糖水平平均为(5.82±1.54)mmol/L,明显低于21例住院患者静脉输注50g/L葡萄糖注射液即刻平均血糖水平为(7.61±2.15)mmol/L(t=2.28,P<0.05);输注后2h血糖水平试验组平均(5.51±1.56)mmol/L,对照组平均为(6.33±2.38)mmol/L,两组比较差异无显著性意义(P>0.05);给药前及给药后2h自身前后血糖水平比较结果显示,试验组患者血糖水平差异无显著性意义(P>0.05);对照组患者血糖水平差异有显著性意义(t=2.84,P<0.05);50g/L果糖注射液对肝、肾功能、血尿液等指标无影响。结论:输注50g/L葡萄糖注射液后血糖水平波动明显小于50g/L葡萄糖注射液,50g/L果糖注射液用于临床患者机体能量补充安全有效。
AIM:To investigate the clinical effectiveness and reliability of D- fructose injection of vein for energy supply by comparing with glucose through their eff ects on blood glucose level of hospitalized patients. METHODS: A randomized double blind parallel controlled clinical trial was per formed.A total of 41 hospitalized patients,who needed energy supply,were randoml y divided into trial group(n=20) and control group(n=21). They received 50 g/L D - fructose or 50 g/L glucose 500 mL/L intraveneouly daily for 3 days.The blood glucose concentrations were estimated before and 0 hour and 2 hours after each a dministration.Liver and renal functions were also tested. RESULTS:Blood glucose level was (1.8± 1.5)mmol/L on everage soon after injec ton of 50 g/L D- fructose,and it was obviously less than that of 21 patients (7 .2± 2.2)mmol/L after injection of 50 g/L glucose.Two hours after injection,bloo d glucose levels in trial and control group were (5.5± 1.6)and (6.3± 2.4)mmol/ L repectively.The difference between them had no statistical significance.Compar ative results of blood glucose level before injection and 2 hours after injectio n showed that patients in trial group had no statistical significance;while pati ents in control group had. CONCLUSION: Blood glucose fluctuation after injecting 50 g/L D- fructose par enteral solution is obviously less than 50 g/L glucose does.5 g/L D- fructose w as efficient and safe for energy supply in hospitalized patients.
出处
《中国临床康复》
CSCD
2004年第3期592-593,共2页
Chinese Journal of Clinical Rehabilitation
