摘要
目的:探讨糖尿病或高血压家族史对人群血压及代谢的影响。方法:采用横断面调查的方法进行研究,完成重庆地区4个社区自然人群3717人的糖尿病和高血压家族史调查,对所有受试者行血压检测及口服葡萄糖耐量试验,以1999年WHO诊断标准明确糖尿病和高血压的诊断。结果:①有糖尿病家族史的人群中高血压检出率明显高于高血压家族史者(31.23%比27.18%,P<0.05),而其中有糖尿病家族史的男性子代高血压的检出率更高,尤其父亲有糖尿病者27.27%比4.35%,(P<0.05);同时其男性子代胰岛素敏感性较女性子代更低(0.46±0.52比0.33±0.78,P<0.05)。②父亲有糖尿病者其女性子代的糖尿病患病率更高(13.04%比9.09%,P<0.05),母亲有糖尿病对两性子代的影响相当。而父母有高血压者均表现为男性子代的高血压患病率高于女性子代(P<0.05)。③无论有糖尿病家族史或高血压家族史者,其男性子代中心性肥胖更明显、三酰甘油更高和高密度脂蛋白胆固醇更低犤如父亲有糖尿病者:腰围(81.07±7.19)cm比(71.83±5.28)cm,P<0.05;三酰甘油2.64±2.68)mmol/L比0.94±0.35)mmol/L,P((<0.05;高密度脂蛋白胆固醇(1.03±0.41)mmol/L比(1.65±0.27)mmol/L,P<0.05犦。结论:父亲的遗传因素对非糖尿病及非高血压男性子代血压及脂代谢的影响较大。
AIM: To explore the effect of diabetes or hypertension family history on blood pressure and metabolism of offspring. METHODS:A cross sectional study was performed to investigate the family history of diabetes or hypertension in 3 717 natural crowd from Chongqing city.Blood pressure was measured and oral glucose tolerance test(OGTT) was conducted in all subjects,and the diagnosis of diabetes and hypertension was made definitely by using the diagnostic standard of WHO in 1999. RESULTS:① The detection rate of hypertension in the subjects with diabetes family history was obviously higher than those with hypertension family history(31.23% vs 27.18% ,P< 0.05),while the detection rate of hypertension was much higher in male offspring with diabetes family history, especially those whose father were with diabetes(27.27% vs 4.35% , P< 0.05);meanwhile,the insulin sensitivity was much lower in male offspring than female offspring(0.46± 0.52 vs 0.33± 0.78, P< 0.05).② The incidence rate of diabetes in female offspring whose father had diabetes was significantly higher than that in male offspring(13.04% vs 9.09% , P< 0.05),while the incidence rates of diabetes were not significantly different between male and female offspring whose mother had diabetes.The incidence rate of hypertension was higher in male offspring than in female offspring whose parents had hypertension(P< 0.05).③ In those with family history of both diabetes and hypertension, there were more remarkable central obesity, higher triglyceride(TG) and lower high density lipoprotein cholesterol(HDL C) in male offspring than female offspring[those whose father had diabetes: waistline:(81.07± 7.19) cm vs(71.83± 5.28) cm;TG:(2.64± 2.68) mmol/L vs (0.94± 0.35) mmol/L;HDL C:(1.03± 0.41) mmol/L vs (1.65± 0.27) mmol/L](P< 0.05). CONCLUSION:Genetic factors of fathers have greater effects on the blood pressure and metabolism of male offspring without diabetes and hypertension.
出处
《中国临床康复》
CSCD
北大核心
2005年第11期4-5,18,共3页
Chinese Journal of Clinical Rehabilitation
基金
重庆医科大学附属第一医院基金(002027)~~
