摘要
目的:探讨血浆三酰甘油(triglyceride,TG)升高与冠心病危险性的关系及影响因素。方法:研究对象均为年龄大于40岁的男性,血浆胆固醇≤5.2mmol/L,近3个月未使用利尿剂、调脂药,无严重的肝肾和甲状腺疾病。然后比较健康对照者和冠心病患者空腹及普通饮食后血脂组分的变化。结果:冠心病组空腹非高密度脂蛋白-载脂蛋白CⅢ(non-HDL-ApoCⅢ)水平显著高于健康对照组(360±20)和(670±50)g/L;冠心病组高密度脂蛋白2-胆固醇明显下降,高密度脂蛋白和低密度脂蛋白颗粒中的TG/胆固醇轻度升高;餐后两组TG浓度均显著增加,但冠心病组增加的幅度更大;冠心病组餐后血浆non-HDL-ApoCⅢ、胰岛素/血糖比值显著高于健康对照组(t=2.8,5.9;P<0.05);TG与血浆non-HDL-ApoCⅢ、血浆胰岛素水平呈显著正相关(r=0.72,0.62;P<0.05)。结论:高TG血症是冠心病的重要危险因子,冠心病患者血浆存在non-HDL-ApoCⅢ浓度升高和胰岛素抵抗现象可能是重要的发病原因。
AIM:To explore the relationship and influencing factors between increase of p lasma triglyceride(TG) and the risk of coronary heart disease(CHD). METHODS:Male subjects over 40 years old were selected,all of them met with the following cri teria:plasma cholesterol level≤ 5.2 mmol/L,without using diuretic and statins f or at least 3 months,and without severe liver, kidney and thyroid gland diseases .The fasting and postprandial plasma lipid changes were compared in patients(stu dy group) with the healthy control group and CHD group. RESULTS:Fasting plasma non- HDL- ApoCIII level in the CHD group[(360± 20) g/L]was significantly higher than that of the control group[(6.7± 0.5) g/L]; high density lipoprotein(HDL)2- Cholesterol in the CHD group decreased signific antly,while the TG/cholesterol ratio of HDL and low density lipoprotein(LDL) par ticles increased lightly;The postprandial TG level significantly increased in th e two groups,but the increase was more significant in the CHD group.The postpran dial non- HDL- ApoCIII and insulin/glucose ratio in the CHD group were signifi cantly higher than those in the control group( t=2.8,5.9;P < 0.05) .Plasma TG level was significantly correlated with non- HDL- ApoCIII and insulin concentr ations(r=0.72,0.62;P< 0.05). CONCLUSION:The hypertriglyceridemia is an important risk factor of coronary h eart disease,and high non- HDL- ApoCIII level and insulin resistance could pla y an important role in the episode of coronary heart disease.
出处
《中国临床康复》
CSCD
2004年第3期450-451,共2页
Chinese Journal of Clinical Rehabilitation
