摘要
目的 :研究轻型急性胰腺炎 (MAP)和重症急性胰腺炎 (SAP)患者的甲状旁腺激素、降钙素 (CT)、血钙的变化及其相互关系。方法 :应用放射免疫法测定所选病例的血清甲状旁腺激素中间片段 (PTH -M )、降钙素 ;用全自动生化分析仪测定所选病例的血清钙离子浓度。结果 :①MAP和SAP患者的急性期和恢复期血清PTH -M与正常对照组比较差异无显著 (P >0 0 5) ;MAP和SAP患者的急性期血清CT显著高于正常对照组 (P <0 0 1) ,而MAP和SAP患者的恢复期血清CT与正常对照组比较差异无显著 (P >0 0 5)。②SAP患者的急性期血清CT与血钙之间存在直线负相关关系 (r =-0 453 ,P <0 0 5)。结论 :重症急性胰腺炎患者 ,低血钙的发生是由于降钙素分泌显著增加所致 。
AIM: To study the changes in serum levels of parathyroid hormone-M (PTH-M), calcitonin (CT) and calcium and their relations in patients with mild acute pancreatitis (MAP) and severe acute pancreatitis (SA P). METHODS: Serum levels of PTH-M, CT were measured by means of r adioimmunoassay, and wholly automatic biochemical analytical apparatus was used to measure serum Ca 2+ concentration. RESULTS: ①Serum leve ls of PTH-M in acute period and convalescen ce of patients who suffered from MAP and SAP had not significant difference comp ared with those in control group (P>0.05). Serum levels of CT in acute per iod of patients who suffered from MAP and SAP were significantly higher than tho se in control group (P<0.01). However, serum levels of CT in recovery of p atients who suffered from MAP and SAP had not significant difference compared w ith those in control group (P>0 05). ②Between serum levels of CT in acut e period of patients who suffered from SAP and serum calcium existed a linear neg ative correlation (r=-0.453, P<0.05). CONCLUSION: The presence of hypocalcemia in patients with severe acute pancreatitis may be due to enhanced secretion of calcitonin. There maybe e xist imbalance of calcemia-parathyroid hormone axis, and an inadequate parathyro id response to hypocalcemia in patients with acute period of SAP.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2004年第1期97-99,共3页
Chinese Journal of Pathophysiology
