摘要
目的 :观察肥胖者血清瘦素水平的变化及糖负荷对瘦素分泌的影响 ,进而探讨瘦素在人类肥胖发生中的作用。方法 :测定 2 0例非肥胖及 2 0例肥胖者空腹及OGTT后血清瘦素、胰岛素、血糖水平 ,同时测定糖化血红蛋白、甘油三酯及胆固醇水平。结果 :(1)肥胖组血清瘦素水平明显高于非肥胖组 (P <0 .0 0 1) ;(2 )与空腹状态相比 ,糖负荷后血清胰岛素水平升高 ,而瘦素水平呈下降趋势 ,但无显著差异 (P >0 .0 5 ) ;(3)相关分析显示 ,空腹血清瘦素水平与性别、体重指数 (BMI)和胰岛素水平具有相关性。结论 :人类肥胖的发生可能与瘦素抵抗而不是瘦素缺乏有关。
Objective: To observe the changes of leptin levels in human obesity and the effect of oral glucose tolerance test (OGTT) on leptin levels. To investingate the relationship between leptin and human obesity. Methods: Fasting levels of leptin, insulin, glucose, hemoglobinA1c(HbA1c), triglycerides and cholesterol were analyzed in 20 normal controls and 20 obese subjects. All subjects received 75g glucose orally and blood samples were taken for the determination of serum leptin, insulin and glucose levels at 0,60,120,180 min. Results: (1) Obese subjects had higher levels of leptin than normal controls (P<0.001). (2) During OGTT, serum insulin levels rose significantly. The leptin release curve showed a decrease pattern during OGTT in both normal weight and obese groups, although no statistical difference was revealed(P>0.05). (3)Serum leptin levels were correlated to sex, body mass index(BMI) and insulin levels. Conclusion: Obesity in humans may be due to leptin resistance rather than to leptin deficiency. It is likely that short-term hyperinsulinemia has no effect on serum leptin levels.
出处
《中国临床医学》
2003年第2期136-138,共3页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金资助 (编号 :3 9970 3 44)
