摘要
目的观察山茶花总黄酮(TFC)对心肌缺血损伤的保护作用,并初步探讨其作用机制。方法采用挟闭气管造成小鼠心肌缺氧模型和舌下静脉注射垂体后叶素(Pit)制备大鼠心肌缺血模型。结果TFC80,40mg/kg显著延长挟闭气管后小鼠心电消失的时间;60,30mg/kg对ivPit引起的大鼠ST段和T波的异常心电图变化有明显的抑制作用,并且能显著减少心肌组织及血清中丙二醛(MDA)含量,抑制血清中乳酸脱氢酶(LDH)活力的升高。结论TFC对心肌缺血有明显的保护作用,其机制可能与抗脂质过氧化有关。
Objective To study the protective effects of total flavone C( TFC) on myocardial ischemia and to explore its mechanism.Methods Two kinds of models were established: mouse model of myocardial ischemia induced by means of clampi ng trachea and rat models of myocardial ischemia induced by pititrin.Results TFC at the concentrations of 80 and 40 mg/kg markedly prolonged the cardioelectric time after clamping the trachea.TFC at the concentrations of 60 and 30 mg/kg can ameliorate the changes of ST and T wave in rat models,reduce the MDA contents in the myocardium and the serum of rats and decrease the activity of LDH in the serum of rats.Conclusion TFC has protective effects on moyocardial ischemia and its mechanism may be related with the inhibition of lipid peroxidation.
出处
《中药新药与临床药理》
CAS
CSCD
2004年第1期25-28,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
