摘要
目的：观察银杏叶总黄酮（ＴＦＧｂ）抗心肌缺血的作用。方法：采用结扎家兔冠状动脉前降支造成急性心肌梗塞的病理模型，用心电图、血清磷酸肌酸激酶活性和梗死面积评价ＴＦＧｂ对心肌缺血的保护作用。结果：ＴＦＧｂ（１６７ｍｇ·ｋｇ－１·ｄ－１，ｉｐ，连续用药１４ｄ）可明显降低心肌梗塞兔ＥＫＧ中ＳＴ段异常抬高的总幅度以及病理性Ｑ波的出现数；并显著抑制心肌组织磷酸肌酸激酶释放。硝基四氮唑蓝染色显示，预先用ＴＦＧｂ可使心肌梗塞范围明显缩小。
Objective: To observe the protective effect of total flavone of Ginkgo biloba (TFGb) on myocardial ischemia. Methods: The experimental myocardial infarction was induced by high level ligation of the anterior descending of the left coronary artery in rabbits. The protective effects were determined by the changes in ECG, the activity of serum creatin phosphorate kinase and infarct sizes. Result: TFGb 16.7 mg·kg -1 i.p. for 14 d remarkably decresed the sum of S T segment elevation (SST) and the number of S T elevating leads (NST) and the number of Q wave (NQ) in ECG. The infarct size as indicated by N BT stainning, was reduced. The activity of CPK in serum was lowered. Conclusions: TFGb have protective effects on experimental myocardial ischemia injury.
出处
《中山医科大学学报》
CSCD
1999年第2期121-123,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
银杏
药理学
黄酮类
心肌缺血
药物疗法
ginkgo biloba /pharmacology
flavone/pharmacology
myocardial ischemia/drug therapy
