摘要
目的:探讨中药丝瓜络(RLF)对小鼠心肌缺血性损伤的防治作用。方法:预先给予昆明小鼠166.7,333.3,666.7g/L的丝瓜络煎剂0.01mL/g灌胃,每日2次,1周后腹腔注射垂体后叶素30U/kg诱发急性心肌缺血,观察心电图变化,检测血清乳酸脱氢酶(LDH)、心肌组织中丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的改变。结果:各种剂量RLF均能降低垂体后叶素所引起的小鼠心电图中T波增高幅度及抑制心率减慢;并显著降低心肌缺血后造成的血清LDH以及心肌组织内MDA含量的增高,增加心肌组织中SOD活性。结论:RLF对急性缺血心肌有明显的保护作用,其作用机制可能与抑制心肌脂质过氧化,增强其抗氧化能力有关。
AIM： To observe the effect of Retinervus luffaefructus （RLF） on the myocardial ischemia in mice. METHODS： Mice were supplied with RLF （166.7,333.3, 666.7 g/L） twice daily （0.01 mL/g, ig）. One week later, 30 U/kg pituitrin was injected intraperitoneally. The electrocardiogram was recorded, and the content of lactose dehydrogenase （LDH） in the serum and the activities of superoxide dismutase （SOD）, maleicdialdehyde （MDA） in the myocardium were examined. RESULTS： RLF reduced the height of T wave in electrocardigram in myocardial ischemia mice and inhibited the decrease in heart rate. RLF also reduced the content of LDH in serum and the content of MDA in myocardium. The increase in the activity of SOD in myocardium was also observed. CONCLUSION： RLF may protect myocardiam against ischemia injury. The mechanism may be related to the increase in activity of SOD and the suppression of the lipid peroxidation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2006年第1期68-71,共4页
Chinese Journal of Pathophysiology
基金
广东省中医药管理局资助项目(No.粤中医[2004]26号)
国家中医药管理局三级实验室开放课题基金资助项目
