摘要
观察冠心病患者凝血、纤溶指标的变化 ,以探讨凝血系统的变化与冠心病发病的关系。采用酶联免疫吸附双抗体夹心法检测 10 0例冠心病患者血浆D 二聚体、血小板α颗粒膜蛋白 14 0及血管性血友病因子含量 ,并与4 4例健康人比较。结果发现 ,冠心病患者血浆D 二聚体、血小板α颗粒膜蛋白 14 0和血管性血友病因子明显升高 ,与对照组比较差异显著 (P <0 .0 1) ,且急性心肌梗死患者各指标变化明显高于陈旧性心肌梗死、不稳定型心绞痛和稳定型心绞痛患者 (P <0 .0 1) ,其中不稳定型心绞痛患者血浆血小板α颗粒膜蛋白 14 0明显高于稳定型心绞痛患者 (P <0 .0 5 )。冠心病患者血小板α颗粒膜蛋白 14 0、血管性血友病因子及D 二聚体水平之间呈明显的正相关性(P <0 .0 5 )。结果提示 ,冠心病患者存在明显的高凝状态 ,表现为继发性纤溶亢进 ,血小板活性增加及血管内皮细胞损伤 ,且与冠心病患者的病情变化有一定关系。
Aim To explore the correlation between incidence of coronary heart disease (CHD) and the changes of markers of coagulation, fibrinolysis in patients with CHD. This may help to diagnosis, anticoagulation, thrombolysis and prognosis for patients with CHD. Methods Plasma platelet granule membrane protein 140 (GMP-140), von Willebrand factor (vWF), D-dimer (D-D) were detected by enzyme linked immunosorbent assay (ELISA) in 100 patients with CHD, and compared with 42 healthy subjects. Results Plasma GMP-140, vWF, D-D were significantly elevated in patients with CHD and differed significantly compared with control group (P<0.01). The changes of molecular markers in patients with acute myocardial infarction (AMI) were elevated significantly than those with old myocardial infarction (OMI), unstable angina (UA) and stable angina (SA) (P<0.01). The levels of plasma GMP-140 in patients with UA were elevated more significantly than those with SA (P<0.05). There were obvious correlations between the molecular markers in patients with CHD(r=0.857～0.301, P<0.01). Conclusions An obvious hypercoagulable state existed in patients with CHD. There were correlations between the changes of molecular markers of hypercoagulable state and patients, condition.
出处
《中国动脉硬化杂志》
CAS
CSCD
2003年第6期567-569,共3页
Chinese Journal of Arteriosclerosis
