摘要
乙酰丹酚酸以Ａ（ＡＳＡＡ）是丹参有效成分衍生物。体外实验表明，ＡＳＡＡ对ＡＤＰ、胶原、ＡＡ和凝血酶诱导的大鼠和兔血小板聚集有明显抑制作用。在半体内实验中，ＡＳＡＡ对多种诱导剂所致血小板聚集也有显著抑制作用，且持续时间达２ｈ以上。此外，在抑制血小板聚集的同时，ＡＳＡＡ对胶原诱导的血小板５－ＨＴ释放也有显著抑制作用。上述结果提示，ＡＳＡＡ可能是一作用广泛的血小板功能抑制剂。
Acetylsalvianolic acid A(ASAA) is an semisynthetic analogue of
salvianolic acidA, isolated from Danshen(Salvia miltiorrhiza
Bunge).In in vitro experiments,ASAA showed markedinhlbitory effect on
rat and rabbit platelet aggregation induced by ADP,
collagen,arachidonic acid(AA) and thrombin. In ex vivo experiments
with ADP,collagen,and AA as inducers, ASAA was alsoshown to inhibit
platelet aggregation remarkably. The effect lasted more than two
hours. In addition,ASAA was found to have suppressive effect on
collagen induced platelet 5-HT release while inhibitingaggregation.
The above results seemed to suggest that ASAA may be a widely
effective inhibitor ofplatelet function.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第6期412-416,共5页
Acta Pharmaceutica Sinica
关键词
丹酚酸
丹参
血小板聚集
Salvianolic acid
Salvia miltiorrhiza
platelet aggregation
Platelet 5-HT release
