摘要
探讨胆固醇酯转运蛋白在 2型糖尿病大血管病变发生中所起的作用及胆固醇酯转运蛋白TaqⅠB基因多态性与大血管病变的关系。对 96例正常对照者及 2 2 6例 2型糖尿病患者的血清胆固醇酯转运蛋白水平及胆固醇酯转运蛋白TaqⅠB基因型进行研究。结果发现 :① 2型糖尿病组胆固醇酯转运蛋白水平较正常对照组明显升高 ,大血管病变组升高更显著 ;②糖尿病大血管病变组B1B1基因型频率 (37.3% )显著高于无大血管病变组(16 .4 % ) ,B1B1基因型大血管病变发生率 (6 8.3% )明显高于B1B2 (4 6 .6 % )和B2B2 (2 9.1% )型 ;③多元回归分析显示 ,高胆固醇酯转运蛋白水平和B1等位基因是 2型糖尿病大血管病变的危险因素。提示 :① 2型糖尿病患者血清胆固醇酯转运蛋白水平升高 ,后者是 2型糖尿病大血管病变的危险因素 ;②胆固醇酯转运蛋白TaqⅠB基因多态性与 2型糖尿病大血管病变发生有关 ,B1等位基因是 2型糖尿病大血管病变的易感基因。
Aim To investigate the association of cholesteryl ester transfer protein (CETP) and CETP TaqⅠB polymorphism with type 2 diabetic macroangiopathy in Chinese. Methods The level of serum CETP was measured by enzyme-linked immunosorbent assay (ELISA) and CETP genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 96 healthy controls and 226 patients with type 2 diabetes mellitus. Results ①The serum level of CETP in type 2 diabetes groups was significantly higher than that in controls, and its level in patients with macroangiopathy was higher than that in patients without macroangiopathy. ②The frequency of genotype B1B1 (37.3%) in type 2 diabetes with macroangiopathy significantly higher than that in patients without macroangiopathy (16.4%). Compared with genotype B2B2 ( 29.1% ) class, the morbidity of macroangiopathy in genotype B1B1 (68.3%) or B1B2 (46.6%) class was significantly increased. ③Multiple logistic analysis showed that the serum CETP and its B1 allele were the important risk factors of type 2 diabetic macroangiopathy. Conclusions ①Serum CETP level rises in diabetic patients and high CETP level may be an important risk factor for type 2 diabetic macroangiopathy. ②CETP TaqⅠB polymorphism is associated with the development and progression of type 2 diabetic macroangiopathy. B1 allele may be a susceptible gene of type 2 diabetic macroangiopathy.
出处
《中国动脉硬化杂志》
CAS
CSCD
2003年第6期549-552,共4页
Chinese Journal of Arteriosclerosis
