摘要
目的 :观察大黄治疗大鼠肠源性肺损伤时内毒素变化。方法 :采用大鼠盲肠结扎并穿孔 (CLP)造成腹腔感染 ,每日在麻醉下经胃管灌注大黄 1次。分别在术前及术后 2 4,48,72 ,96,12 0h处死 1组大鼠 ,检测肺毛细血管通透性、支气管肺泡灌洗液 (BALF)的中性粒细胞百分率 ,分析血浆、肺组织和BALF的内毒素水平。结果 :肺毛细血管通透性、BALF的中性粒细胞百分率及血浆、肺组织和BALF的内毒素含量逐渐增加 ,时间越长作用越明显。治疗组比感染组增加较慢、幅度较小。结论 :大黄可阻止肺组织的内毒素含量和中性粒细胞数量的增加 ,减轻肺损伤。
Objective:To observe the change of endotoxin in gut derived lung injury treated by rhubarb. Method:The cecal ligation and perforation(CLP) was utilized to produce abdominal infection in rats and rhubarb was poured into the stomaches of anesthetized rats once every day. Six groups were sacrificed respectively before operation and 24,48,72,96 and 120 hours after operation. The pulmonary vascular permeability and the neutrophil percentage of bronchoalveolar lavage fluid (BALF) were detected. The concentrations of endotoxin in plasma, lung and BALF were assayed. Results:The pulmonary vascular permeability, the neutrophil percentage of BALF, and the concentrations of endotoxin in plasma, lung and BALF increased progressively, but they increased more slowly and less in degree in the treatment-group than in the infection-group. Conclusion:Rhubarb can significantly modify lung injury through preventing increase of endotoxin and neutrophils in lung tissue.
出处
《医药导报》
CAS
2004年第1期13-15,共3页
Herald of Medicine
