摘要
目的 对多发性肌炎 (PM)、皮肌炎 (DM)患者的食管运动功能进行研究 ,对部分患者治疗前后的结果进行比较 ,以研究PM、DM食管运动功能障碍的特点及其对治疗的反应。方法 PM患者 12例、DM患者 18例 ,其中食管症状组 16例 ,非食管症状组 14例。患者在确诊后进行激素和 /或免疫抑制剂治疗 ,治疗 3个月后 ,14例有食管症状的患者再次重复食管测压。并与健康对照组 30名进行各项指标的比较。结果 ①PM、DM患者食管测压示病例组远端食管蠕动压 (PA)、传导时间(PD)、传导速度 (PV)与健康对照组相比差异有显著性 (P <0 0 5 ,P <0 0 1)。②食管症状组下段食管括约肌压力 (LESP)、松弛率 (LESR)、PA、PD、PV与健康对照组和非食管症状组相比差异有显著性(P <0 0 5 ,P <0 0 1)。③治疗后LESP、LESR、PA提高 ,以PA改变尤为明显。④治疗前后食管异常收缩波的百分比 :治疗前同步收缩的百分比为 2 1% ,治疗后为 1% (P <0 0 0 1)。结论 PM、DM出现食管运动障碍 ,有食管症状组较非食管症状组食管受累更为明显 ,治疗后随病情好转食管运动功能障碍得到改善。
Objective To investigate the esophageal motility in polymyositis (PM) and dermato myositis (DM).Methods Esophageal manometry was performed in 30 healthy subjects,12 patients with PM and 18 patients with DM before and after treatment (prednisolone or immunosuppressant).Results ① In PM and DM groups,PA,PD and PV were significantly abnormal compared with control group (P<0.05,P<0.01).② There was significantl difference between esophageal symptom group and healthy subjects in LESP,LESR,PA,PD and PV.③ After treatment,LESP,LESR and PA were improved,especially PA.④ The percentage of abnormal peristalsis was 21.4% and 1.1%(P<0.001) before and after treatment,respectively. Conclusion There is esophageal motility disorder in PM and DM,especially in esophageal symptom group.After treatment the abnormality is improved.
出处
《中华风湿病学杂志》
CAS
CSCD
2003年第12期746-748,共3页
Chinese Journal of Rheumatology
