摘要
目的 :探讨缺氧诱导因子 1α(HIF 1α)和血管内皮细胞生长因子 (VEGF)在前列腺癌中的表达及其与病理分级、临床分期的关系。方法 :采用免疫组化方法检测前列腺癌和良性前列腺增生 (BPH)组织中HIF 1α和VEGF的表达。结果 :前列腺癌中HIF 1α和VEGF的表达均明显高于BPH ;HIF 1α和VEGF在前列腺癌中的表达水平与其病理分级和临床分期均呈正相关 ;前列腺癌中的HIF 1α表达水平和VEGF的表达水平呈正相关。结论 :HIF 1α和VEGF是检测前列腺癌的较好分子标志物 ,可望用于前列腺癌的辅助诊断和预后判断 ,HIF 1α是VEGF表达的调控因子之一。
Objective:To evaluate expression of HIF-1α and VEGF in prostate cancer, and study relationship between their expression and the pathological grade, clinical stage in prostate cancer.Methods:HIF-1α and VEGF were detected by immunohistochemistry method in tissues of prostate cancer and BPH.Results:HIF-1 and VEGF levels in prostate cancer were much higher than those in BPH; the degree of cancer malignant and invasion positively correlated with the expression of HIF-1α & VEGF; HIF-1α level positively correlated with VEGF level.Conclusions:HIF-1α and VEGF are good molecular markers of prostate cancer which can be used to assist diagnosis and predict prognosis; HIF-1αis one of important regulator of VEGF.
出处
《临床泌尿外科杂志》
2004年第1期36-38,共3页
Journal of Clinical Urology
