摘要
目的观察辣椒素经鼻给药后对小鼠行为及鼻黏膜形态学的影响。方法使用不同浓度的辣椒素液体给小鼠滴鼻,连续7d,观察滴鼻过程中小鼠的反应,并在停止给药1wk、3wk、4wk后分别取鼻黏膜在光学显微镜和电子显微镜下行形态学观察。结果经鼻给辣椒素后头3d,小鼠有不同程度的行为反应,3d后对辣椒素滴鼻多可适应。停药1wk后,光镜及电镜观察,鼻黏膜上皮细胞部分区域的纤毛排列紊乱、脱落,随药物浓度的减低,形态学改变逐级减轻;停药4wk后,纤毛及上皮细胞逐渐修复。结论辣椒素短期局部给药对鼻黏膜的影响是可逆的,经鼻给药是一种可行的用药途径。
Purpose To study the morphological changes of intranasal applications of capsaicin to the rat nasal mucosa. Methods The capsaicin solution of different concentration was applied to the rat nasal cavity for seven days , and the response of the rats was recorded. One week, three weeks and four weeks after the capsaicin applications, the nasal mucosa was taken out and analyzed under optical and electron microscopes. Results It was found that the rats were adapted to capsaicin after three days of the administration. One week after the capsaicin applications, damages of the nasal mucosa were observed. In some regions the cilia were detached from the epithelia. The degree of the mucosa damage was increased with the solution concentration. Four weeks after the capsaicin administration, the ciliated epithelia were restored gradually. Conclusion The damage of the nasal mucosa induced by short-term intranasal administration of capsaicin is reversible. The intranasal application of capsaicin is feasilble , and convenient.
出处
《中国眼耳鼻喉科杂志》
2003年第6期350-352,共3页
Chinese Journal of Ophthalmology and Otorhinolaryngology
