摘要
目的：了解Ｇｑ 蛋白α亚单位（Ｇαｑ）与原发性高血压的相关性。方法：以Ｇαｑ的多克隆抗体为探针，用免疫印迹（Ｉｍ ｍ ｕｎｏｂｌｏｔ）方法测定人动脉平滑肌层中Ｇαｑ的相对含量。结果：大肠癌患者中原发性高血压病人组（ｎ＝ ９）与对照组（ｎ＝ １５）相比较，血管平滑肌层中Ｇαｑ含量无显著性差异。结论：这可能是由于抗高血压药物作用的结果，也可能是另一条信号传导途径——酪氨酸激酶介导的磷脂酶Ｃ途径的异常。
Objective:To investigate the relationship between Gq protein α subunit (G αq ) and essential hypertension.Method:The relative contents of G αq in arterial smooth muscle tissue were determined by immunoblot technique with G αq polyclonal antibody as probe.Results:There was no statistically significant difference of G αq contents in arterial smooth muscle between patients with essential hypertension ( n =9) and control ( n =15).Conclusion:The results may be caused by administration of antihypertensive medicines,or the abnomarity of another signal pathway——tyrosine kinase mediated activation of PLC γ or no role played by G αq and PLC during the pathogenesis of essential hypertension.
出处
《浙江大学学报（医学版）》
CAS
CSCD
1999年第6期245-247,共3页
Journal of Zhejiang University(Medical Sciences)
基金
国家和浙江省自然科学基金
