摘要
目的：探讨侵袭性骨肿瘤ＤＮＡ含量与肿瘤良恶性程度及预后的关系。方法：用流式细胞术对２０例经手术治疗取得的新鲜侵袭性骨肿瘤组织标本作ＤＮＡ含量测定，并与病人复发情况作相关分析。结果：二倍体及低ＤＩ、Ｓ％ 、ＰＩ的侵袭性骨肿瘤复发率低，异倍体及高ＤＩ、Ｓ％ 、ＰＩ者复发率高。结论：二倍体侵袭性骨肿瘤具有良性倾向，宜采用刮除加灭活及边缘切除等手术方式，而异倍体侵袭性骨肿瘤具有恶性倾向，宜采用肿瘤广泛切除甚至截肢等手术方式。
Objective:To measure nuclear DNA content of invasive bone tumor with flow cytometry(FCM) and to analyse the relationships between DNA content and prognosis of disease.Methods:From March 1992 to March 1993,20 fresh surgical specimens from patients with primary invasive bone tumor was measured for DNA content with FCM,all patients were followed up at least for 6 years.Results:Patients with DNA diploid,lower S phase cell percentage,PI had lower recurrence rate,but patients with aneuploid,and highter S%、PI had higher recurrence rate.Conclusion:This study indicates that patients with diploid be inclined to binign,the resection can be bordered or scraping and extinctive,while patients with DNA aneuploid be inclined to malignant and the extend of local resection of turmors should be more extensive or radical.
出处
《浙江大学学报（医学版）》
CAS
CSCD
1999年第5期196-198,205,共4页
Journal of Zhejiang University(Medical Sciences)
