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BMP-7 mRNA在大鼠缺血/再灌注心肌和脑中表达的变化 被引量：3

Changes of BMP-7 mRNA Expression in Cardiac and Cerebral Ischemia/Reperfusion in Rats
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摘要 目的 :观察骨形态构建蛋白 (BMP) 7mRNA在大鼠心肌和脑缺血 /再灌注中表达的改变。方法 :Wistar大鼠 32只 ,随机分成 4组。各组大鼠经过不同处理 ,处死后心肌、脑组织标本放入液氮中保存并行RT PCR检测BMP 7mRNA表达的改变。结果 :心肌对照组BMP 7mRNA表达丰度为 1.14± 0 .0 8;心肌缺血 /再灌注组有明显降低(丰度为 0 .90± 0 .0 5 ,P <0 .0 5 ) ,脑缺血 /再灌注组的BMP 7mRNA表达 (丰度 1.0 4± 0 .0 5 )与脑对照组 ( 1.17± 0 .0 9)相比明显降低 (P <0 .0 5 )。结论 :心肌和脑缺血 /再灌注损伤使BMP 7mRNA表达明显减弱 ,提示BMP 7基因mRNA表达与机体缺血 Objective: Our aim was to observe changes of bone morphogenetic protein (BMP) 7 mRNA expression in cardiac and cerebral ischemia/reperfusion(I/R) in rats. Methods:Rats 32 were divided into 4 groups randomly (8 in each). Rats in different groups were killed after receiving different treatments. Expression of BMP 7 mRNA was measured with RT PCR in cardiac and cerebral tissues of rats. Results:The expression of BMP 7 mRNA in cardiac control group was 1.14±0.08, while remarkably decreased to 0.90±0.05 in cardiac I/R group (P<0.05). In cerebral I/R group, the expression of BMP 7 mRNA was 1.04±0.05, which was significantly lower than that in control group (1.17±0.09,P<0.05). Conclusion:Cardiac and cerebral I/R might lead to the decrease of BMP 7 mRNA expression, which implied that BMP 7 gene was closely related to the injuries caused by I/R
作者 袁治国 王俊科
机构地区 中国医科大学附属第一医院麻醉科
出处 《中国医科大学学报》 CAS CSCD 北大核心 2003年第6期496-497,共2页 Journal of China Medical University
关键词 骨形态构建蛋白 心 脑 缺血/再灌注 bone morphogenetic proteins heart brain ischemia/reperfusion
分类号 Q344 [生物学—遗传学] Q463 [生物学—生理学]
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参考文献6

  • 1Ducy P, Karsenty G. The family of bone morphogenetic proteins [J]. Kidney Int, 2000,57(6) :2207 -2214.
  • 2Reddi AH. Bone morphogenetic proteins: from basic science to clinical applications['J]. Bone Joint Surg Am, 2001, 83 -A(pt 1 ):S1 -6.
  • 3Miyazono K. Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins[J]. Bone, 1999,25( 1 ) :91 -93.
  • 4Kawabata M, Imamura T, Miyazono K. Signal transcluction by bone morphogenetic proteins [" J ]. Cytokine Growth Factor Bey, 1998,9(1) :49-61.
  • 5Dudley AT, Robertsun EJ. Overlapping expression domain of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos[J]. Dev Dyn, 1997,208(2) :349 -362.
  • 6Liu Y, Belayev L, Zhao W, et al. The effect of bone morphogenetic protein-7 (BMP-7) on functional recovery, local cerebral glucose utilization and blood flow after transient focal cerebral ischemia in rats [J]. Brain Res, 2001,905( 1 -2): 81 -90.

同被引文献17

  • 1Chang CF,Lin SZ,Chiang YH,et al.Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats[J].Stroke,2003;34(2):558-64.
  • 2Nakamura T,Xi G,Hua Y,et al.Nestin expression after experimental intracerebral hemorrhage[J].Brain Res,2003;981(1-2):108-17.
  • 3Chen HL,Lein PJ,Wang JY,et al.Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals[J].Brain Res,2003;994(1):81-90.
  • 4Horbinski C,Stachowiak EK,Chandrasekaran V,et al.Bone morphogenetic protein-7 stimulates initial dendritic growth in sympathetic neurons through an intracellular fibroblast growth factor signaling pathway[J].J Neurochem,2002;80(1):54-63.
  • 5Wang Y,Chang CF,Morales M,et al.Bone morphogenetic protein-6 reduces ischemia-induced brain damage in rats[J].Stroke,2001;32(9):2170-8.
  • 6Dattatreyamurty B,Roux E,Horbinski C,et al.Cerebrospinal fluid contains biologically active bone morphogenetic protein-7[J].Exp Neurol,2001;172(2):273-81.
  • 7Setoguchi T,Yone K,Matsuoka E,et al.Traumatic injury-induced BMP7 expression in the adult rat spinal cord[J].Brain Res,2001;921(1-2):219-25.
  • 8Yanagisawa M,Takizawa T,Ochiai W,et al.Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins[J].Neurosci Res,2001;41(4):391-6.
  • 9Aberle H,Haghighi AP,Fetter RD,et al.Wishful thinking encodes a BMP type Ⅱ receptor that regulates synaptic growth in Drosophila[J].Neuron,2002;33(4):545-58.
  • 10Chang CF, Lin SZ, Chiang YH, et al. Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats[J]. Stroke, 2003, 34(2):558-564.

引证文献3

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中国医科大学学报
2003年 第6期

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