摘要
熟地黄具有抗焦虑作用。其作用机制传统认为系通过滋补肾阴 ,以益阴制阳 ,平衡阴阳 ;现代认为作用机制可能为抑制中枢神经系统 ,增加γ -氨基丁酸 (GABA)递质含量及受体表达 ,抑制下丘脑 -垂体 -肾上腺 (HPA)轴机能亢进 ,恢复HPA轴机能平衡。研究熟地黄抗焦虑作用机制宜在符合中医阴虚证候 ,GABA系统功能低下的焦虑动物模型上进行。
Prepared Radix Rehmanniae has anti-anxiety function. Traditionally, it is believed to balance yin and yang by nourishing kidney yin. Presently however, it is thought to restrict the center nervous system, increase the cotent of GABA and the expression of itsreceptor, inhibit hyperfuction of the HPA axis and restore its balance; The study of prepared Radix Rehmanniae should be performede on the model with hyperfuction of GABA system and yin deficiency.
出处
《河南中医学院学报》
2003年第6期67-69,共3页
Journal of Henan University of Chinese Medicine
关键词
焦虑症
熟地黄
阴虚
动物模型
anxiety
prepared Radix Rehmanniae
yin deficiency
animal models
