摘要
目的 探讨不同原因引起的休克时,机体抗凝血酶和纤维蛋白溶解功能的变化及临床意义。方法 研究67例不同原因引起休克的患者,按病因分为感染性休克23例、创伤性休克18例、心源性休克26例。在发生休克时采集上标本,STAGO-STA自动血凝仪上发色底物法测定血浆抗凝血酶活性(AT:A)和纤溶酶原活性(PLG:A);免疫比浊法测定血浆D-二聚体(D-D)及凝固法测定纤维蛋白原(FIB)含量并与正常对照组进行比较分析。结果 3组休克患者AT:A和PLG:A均显著低于对照组(分别为P<0.05、P<0.01和P<0.001);D-D含量均非常显著的高于对照组(P<0.001);FIB含量除创伤性休克外其余2组均明显高于对照组(P<0.01)。3组休克间比较,经方差分析,除D-D含量无区别外,其余项目各组间均存有显著性差异(P<0.01)。结论 休克发生时血浆抗凝血酶活性降低,继发性纤溶功能增强,提示机体处于血栓前状态,应积极采取相应措施防止DIC的发生。
Objective To investigate the changes of antithrombin and fibrinolyic function in the patients with shock for different
reason. Method 67 patients with the diagnosis of shock were studied. All the patients were divided into infectious shock, traumatic shock and
cardiogenic shock group. Blood samples were taken on the day after hospital admission to measure antithrombin activity(AT: A), plasminogen
activity (PLG:A), D-dimer(D-D) and fibrinogen(FIB). All the samples were analyzed in STAGO-STA. Results Compared with the
control group. shock groups showed significant decrease in PLG:A and AT:A (P<0.05, P<0.01 and P<0.001 respectively). All shock
groups showed greatly significant increase in D-D (P<0.001), and shock groups showed significant increase in FIB (P<0.01) except
traumatic shock. ANOVA analysis showed significant difference in AT: A, PLG: A and FIB between shock groupe except D-D (P<0.01).
Conclusion The present results indicated that patients were in prethrombotic state at the beginning of shock. It was suggested that we should
do something to protect patients from DIC.
出处
《中国急救医学》
CAS
CSCD
北大核心
2003年第11期772-773,共2页
Chinese Journal of Critical Care Medicine
