摘要
目的：监测急性心肌梗塞（ＡＭＩ）溶栓治疗中凝血和纤溶系统的改变，预防出血和再灌注失败。方法：用单克隆抗体乳胶凝集法测定ＡＭＩ患者溶栓治疗前、后Ｄ－二聚体含量，同时监测ＰＴ、ＦＩＢ、ＰＩＧ、ａ＿２－ＡＰＬ、ＡＴ－Ⅲ等凝血和纤溶指标的改变。结果：Ｄ－二聚体含量治疗后与治疗前相比有极显著差异，其增高持续的时间、ＦＩＢ、ＰＬＧ、ａ＿２－ＡＰＬ在溶栓治疗后极明显下降的时间和冠脉再通的时间相吻合。结论：上述指标对溶栓治疗的监测和预后的评估均有重要意义。
Objective. The fibrinolytic activity status of the patients with AMI can affect their clinical prognosis. Methods. The concentrations of D- dimer in plasma by Latex agglutination assay before and after thrombolytic treatment in 15 patients suffering from their early attacking acute myocardial infarc-tion(AMI)were measured. So were antithrombinⅢ(AT-Ⅲ).plasminogen(PLG). α_2-antlplasmin(α_2 APL). fibrinogen(FIB). prothrombin time (PT).Results. Compared to the pretreatment values. D-dimer increased markedly. and FIB. PIG . α_2-APL decreased.Conclusions. These findings indicate that fibrinolytic activity enhanced during the use of the thrombolytic agent. An understanding of this is very important in increasing the successful rate of thrombolytic therapy and preventing reocclusion.
出处
《北京医科大学学报》
CSCD
1996年第2期121-123,共3页
Journal of Peking University(Health Sciences)
关键词
心肌梗塞
药物疗法
血栓溶解
Headings Myocardial infarction/drug ther
Thrombolytic therapy
D- dimer
Fibrino-gen/blood
Prothrombin time
