摘要
目的探讨肝、肾及肝肾联合移植患者围手术期及恢复期血浆AT活性测定的动态变化及其临床意义。方法观察了176例各类终末期肝病患者、69例肾病患者、16例肝肾综合征患者在围手术期间血浆AT活性的动态变化。均于术前、术中、术后10d每天抽取静脉血,用发色底物法测定AT活性,并给予分析。结果3组患者术中、术后早期血浆AT活性降低,恢复期AT的活性逐渐升高;肾脏移植组AT活性的恢复最快,与其它两组有显著差异性,而肝移植组与肝肾联合移植组AT的恢复无显著差异性。结论AT活性的恢复是衡量移植物成功的较好指标之一;术后早期受者血液的抗凝作用减弱,处于危险的血栓形成高凝状态之中。
Objective To explore the detection of antithrombin activity （AT：A） in patients during surgery period and the recovery period to forecast after liver transplantation , kidney transplantation , combined liver- kidney transplantation. Methods observed alterations of AT- A in 176 cases of end- stage liver disease in liver transplant patients ,69 cases nehprotic syndrome, 16 cases hepatorenal syndrome during surgery period . All the samples were obtained at preoperative stage and every day after operation and analyzed by the substrate linked with color assay in CA7000. Results In contrast to preoperative stage AT：A gradually decreased before reperfusion and gradually increased in recovery period, In comparison to the other groups there was significant difference in kidney transplantation . AT：A did not display significant changes between liver transplantation and combined liver-kidney transplantation. Conclusion It is very important to measure AT ： A in predicating the success of transplantation . anti- coagulant functions were deceased at the early stage. It indicated the risk of potential thrombosis.
出处
《血栓与止血学》
2009年第3期122-124,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
抗凝血酶
肝脏移植
肾脏移植
肝肾联合移植
Antithrombin activity
Liver transplantation
Kidney transplantation
Combined liverkidney transplantation
