摘要
目的 探讨细胞核因子 κB(NF κB)与大肠癌发生、转移和治疗的关系。方法 采用文献回顾的方法对NF κB的结构和分子生物学特性 ,以及与细胞凋亡、恶性肿瘤、大肠癌的关系进行综述。结果 NF κB具有抗凋亡作用 ,与恶性肿瘤的发生、转移密切相关 ,并通过对原癌基因 (c myc)、环氧合酶 (Cox2 )、细胞间粘附分子 (ICAM 1 )的调控 ,影响大肠癌的发生、转移。结论 NF κB对大肠癌的发生、转移具有重要作用 。
Objective To explore the relationship between nuclear factor κB (NF κB) and the occurrence, metastasis, and treatment of colon cancer. Methods The literature on the structure and the property of molecular biology of NF κB, the relationship between NF κB and apopotosis, malignant tumor and colon cancer were reviewed.Results NF κB had action of antiapopotosis. The occurrence of malignant tumor had close relation with the oncogene by NF κB, the metastasis of malignant tumor was that cell of cancer escaped the killing and supervising of immunity by NF κB. NF κB affected the occurrence and metastasis of colon cancer by regulating c myc, Cox2, ICAM 1.Conclusion NF κB has important action in the occurrence and metastasis of colon cancer. It will become a new target of treatment.
出处
《中国普外基础与临床杂志》
CAS
2003年第2期173-175,共3页
Chinese Journal of Bases and Clinics In General Surgery
